HIV Flashcards
Spread through
-blood, semen, breast milk, vaginal secretions
Sexual contact
-Genital, anal, oral
Parental
- IV drug use, blood transfusion
Perinatal
-placenta, maternal blood, delivery, breastmilk
Risky behavior….. who is likely to be more infected
- females from infected males
Anal intercourse is highest risk - Higher viral load > higher chance
Prevention via sexual transmission
- ABCD
- Abstinence, being faithful, condom use, Drugs
- PEP
Prevention through parental transmission
- use of cleaning needles with diluted bleach
- needle excahnge programs
- PrEP
- Blood donation screening
Perinatal prevention
- Drup therapy drops risk of transmission
- babies born to mothers with HIV should betreated with meds 4-6 weeks after delivery
- Cesarean delivery
- no breastfeeding
For HCW
- Common route is dirty needle stick
- may come from infected wounds and body fluids
- use standard precautions
- Sharps injury prevention
- PEP
4th generation testing
- Blood 4th gen HIV assay
-Detects HIV antibodies (HIV IgM and IgG) within 21 days
-Detects p24 antigen (HIV capsid protein) within 14 days
If positive-> test for HIV-1 vs HIV-2
NAT (nucleic acid test) looking for HIV RNA (acute infection
Home testing kits
Transmucosal exudate- results in 20 minutes
Drop of blood
If test is +, results should be verified with further testing
Viral Load
- Measures amount of HIV virla RNA particles in blood
- The higher the viral load, the greater the risk of transmitting
- Can detect as little as 40 particles/ mL - 80,000 particles
- For HIV infectivity and therapy effectiveness
Other diagnostic testing
-Lymphocyte count, Cd4 count, Viral load testing/ Quant RNA assays, CBC, CMP, Toxoplasmosis antibody titer, LFT, HEp A,B,C, Lipid profile, Syphilis
If they have syphillis
needs to be tested once a year
1) Acute HIV infection
flu- like symptoms
VEry contagious/ high viral load
2) Chronic HIV infection (asymptomatic)
- HIV active and reproducing slowly
- Lasts ten years, untreated
- Can transmit HIV to others
- With medication some people remain in this pahse indefinitely
3) AIDS
- Immune system is severely damaged
- CD4+ count is below 200 cells/ mm
- or they develop opportunistic infections
- Without treatment, death occurs in about 3 years