HIT Flashcards
how is thrombocytopenia defined
platelet count <150,000 mcL
what is normal platelet count
150-400,000
HIT is a _____-mediated reaction that increases thrombosis
antibody
type I HIT
non-immune, transient
hype II HIT
immune-mediated, clinically significant
what is the incidence of HIT
1-3%
is LMWH or UFH more likely to cause HIT
UFH
are therapeutic or prophylactic doses more likely to cause HIT
therapeutic
are surgical or medical patients more likely to have HIT
surgical
HIT is a _____ syndrome
hypercoagulable
summarize HIT pathophysiology?
thrombin generation, platelet activation and microparticle release, HIT Ab binding to endothelial cells–> vascular injury and tissue factor release
thrombocytopenia results from _____ and ____
platelet aggregation and consumption
hypercoagulable means increased risk of ___
clot
how many days does it take to form an antibody
5-10
if the patient had prior exposure to heparin, HIT can occur ___
rapidly (<1 day)
