History of Pharmacy Practice Flashcards

1
Q

first soothing
application

A

Cool water, a leaf, dirt, or mud

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2
Q

Human beings seek natural cures for their ailments

A

plants, animals and
minerals

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3
Q

called the cradle of
civilization, provides the earliest known
record of practice of the art of
apothecary.

A

Around 2400 BC- Babylon, of ancient
Mesopotamia,

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4
Q

Practitioners of healing in this era were

A

priest, pharmacists and physicians

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5
Q

the
first sign of the sickness, the prescription,
and the compounding instructions were
written

A

On clay tablets or Sumerian cuneiform,

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6
Q

an emperor sought
out and investigated the medicinal value of several
medicinal herbs.

A

Around 2000 BC- SHEN NUNG,

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7
Q

written by Shen Nung, is a collection of
365 native herbs

A

Pen T-Sao

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8
Q

Medicinal plants include:

A

podophyllum, rhubarb,
ginseng, stramonium, cinnamon bark, ma huang or
ephedra

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9
Q

a medicinal record
from Ancient Egypt contains a collection of 800
prescriptions, 700 medications, and some recorded
formulas for lotions, inhalations, gargles, tablets,
ointments, and poultices

A

Around 1500 BC- “Papyrus Ebers”

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10
Q

among the greatest
early Greek philosophers and natural scientists, is
called- the Father of Botany
– He holds belladonna, behind him are pomegranate
blooms, senna, and manuscript scrolls
– Used as slates were slabs of ivory, coated with colored
beeswax

A

Around 300 BC- THEOPHRASTUS

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11
Q

an early “trademarked” drug.
* A clay tablet made on the
Mediterranean Island of Lemos which
holds medicinal tablets that carry a
trademark, to identify the source and
inspire trust in their products

A

Around 500 BC- Terra Sigillata (Sealed
Earth),

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11
Q

Around 600 BC- The earliest
recorded occurrence of a
compounded medication in
INDIAN Traditional medicine is
found in

A

SUSHRATA SAMHITA

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12
Q

Two or more echelons:

A

Gatherers and preparers of drugs
* “Chiefs of fabrications”, or head pharmacists
– They worked in the “House of Life”

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13
Q

the royal toxicologist

A

Mithridates VI

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14
Q

He is remarkable in Pharmacy history and is called the
Royal Toxicologist where his widely recognized
MITHRIDATUM was used as a poisonous substance
antidote

A

Mithridates VI- King of Pontus

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15
Q

He pursued to discover the art of poisoning, avoiding
poison, and treating it.

A

Around 100 BC- Mithridates VI- King of Pontus

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16
Q

was used as a poisonous substance
antidote

A

MITHRIDATUM

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17
Q

He experimented on himself and his prisoners for poisons
and antidotes which leads him to create one against all
kinds of poison

A

Mithridates VI- King of Pontus

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18
Q

a
notable individual who made substantial
contribution in Pharmacy Practice.

A

Around 1

st Century A.D.- Pedanios Dioscorides

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19
Q

commonly known as GALEN, was a Roman Greek physician,
surgeon, and philosopher.
– The first physician to use the pulse as a sign of illness
– His name still is associated with that class of

pharmaceuticals compounded by mechanical means-
Galenicals

– Originator of the formula for a cold cream

A

Around 130-200 AD- Aelius Galenus or Claudius Galenus

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19
Q

His work, DE MATERIA MEDICA is a record of his findings
and specifications for the acquisition, storage, and usage
of medications. It has a record of nearly 500 plants and
remedies prepared from plants, animals and metals.

A

Pedanios Dioscorides

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20
Q

Because they refused payment for their services, they
were called the “silverless ones.” Their tomb in the Syrian
City of Cyprus was made a shrine and many miracles
were attributed to them

A

DAMIAN- the apothecary
– COSMAS- the physician

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20
Q

Twin brothers of Arabian descent, and devout Christian

A

DAMIAN- the apothecary
– COSMAS- the physician

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21
Q

who contributed greatly to the pharmacy
practice by compiling texts, in which he introduced the use of
“mercurial ointments” and his development of apparatus such
as mortars, flasks, spatulas and vials, which were used in
pharmacies until the early twentieth century.

A

One of the greatest Arab physicians was Abu Bakr al-Razi or
Rhazes (Latin name)-

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22
Colonial America’s first Hospital
(Pennsylvania) was established in Philadelphia in 1751. – Pennsylvania Hospital was founded in 1751 by Dr. Thomas Bond and Benjamin Franklin "to care for the sick-poor and insane who were wandering the streets of Philadelphia."
23
America’s first Hospital Pharmacist was
Jonathan Roberts,
23
a German Swedish Pharmaceutical- Chemist, made a thousands of experiments, discovered oxygen, chlorine and manganese
Carl Wilhelm Scheele (1742- 1786),
23
a German pharmacist give the world opium’s chief narcotic principle: Morphine
Friedrich Wilhelm Adam Serturner (1783- 1841),
24
He was one of the most outstanding pharmacists who significantly influenced the transformation of pharmaceutical chemistry from a state of alchemistry to an acknowledged branch of science at the end of the 18th century.
Friedrich Wilhelm Adam Serturner
24
He proved the importance of a new class of organic substances: Alkaloids
Friedrich Wilhelm Adam Serturner
25
26
27
28
29
29
It helped regulate the practice of dispensing medicine and encouraged pharmacists to develop close relationships with the doctors who prescribed the medicine.
The American Pharmaceutical Association (1852)
30
was the patriarch of American pharmacy: a founder of the first college of pharmacy in the United States (Philadelphia College of Pharmacy in 1821), the first American pharmacy journal, and the first national professional association.
Daniel B. Smith (1792- 1883)
30
He was a practitioner, experimenter, editor, association leader and professor.
– Although the designation “Father of American Pharmacy” fell to his young protégé and colleague William Procter Jr. (1817- 1874).
30
– A group of 11 physicians met at the US Capitol in Washington DC, the result of which was the creation of the first United States Pharmacopeia (published as The Pharmacopoeia of The United States of America). – The first editions were very basic, and aimed only to serve as “authoritative” resources for the public to consult.
“United States Pharmacopoeia” (1820)
31
principally aimed to serve as a resource and a formulary for small-scale compounding of medicines.
Independently of the United States Pharmacopeia, the American Pharmaceutical Association established the National Formulary (NF) in 1888. The NF
32
contains monographs and standards for medicines, finished dosage forms, active drug substances, excipients, biologics, compounded preparations, medical devices, dietary supplements, and many other therapeutic goods intended for use in healthcare.
The USP-NF
33
opened vast new horizons for the advancement of Pharmacy and medicine. He was an American explorer, botanist, and pharmacist.
Scientific adventurers, such as Henry Hurd Rusby (1855- 1940),
34
He collected more than 60,000 botanical specimens and described nearly a thousand new species of plants. Three genera , Rusbya Britton, Rusbyanthus Gilg, and Rusbyella Rolfe ex Rusby, numerous species, and the alkaloid rusbyine bear his name. He is cited as the author of 49 taxon names.
Henry Hurd Rusby
35
a German medical scientist, published his memoir, ‘The Potency Estimation of diphtheria antiserum and its theoretical basis’, which laid the foundation for all future work on biological standardization
Paul Ehrlich (1854- 1915),
36
Biological products (made from microorganisms) got their start with the discovery of diphtheria antitoxin by
Behring and Roux in 1894.
37
Pharmaceutical manufacturers since have constantly improved serums, antitoxins, and vaccines, which have saved countless lives.
38
is also known for his pioneering work in hematology, immunology, and chemotherapy and for his discovery of the first effective treatment for syphilis
Paul Ehrlich (1854- 1915),
39
also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first effective treatment for syphilis, relapsing fever, and African trypanosomiasis.
Arsphenamine,
39
a French pharmacist who worked for 30 years and headed chemical laboratories in the world-renowned Institut Pasteur, in Paris. He developed Stovaine in 1904.
Ernest Francois Auguste Fourneau (1872- 1949),
40
is used as a spinal anesthesia. It contains Amylocaine, the first synthetic and non-addictive local anesthetic.
Stovaine
41
His early work with bismuth and arsenic compounds advanced the treatment of syphilis and paved the way for the development of sulfonamide drugs and antihistamines.
Ernest Francois Auguste Fourneau
42
successfully isolated the hormone insulin for the first time. – The breakthrough research took place at the University of Toronto, where Banting and Best successfully isolated insulin from dogs, produced diabetes symptoms in the animals, and then provided insulin injections that produced normal blood glucose levels.
In 1921, Dr. Frederick Banting, a Canadian surgeon, and Charles Best, a medical student,
43
in Germany was possibly the earliest company to move in this direction. Originating as a pharmacy founded in Darmstadt in 1668, it was in 1827 that Heinrich Emanuel Merck began the transition towards an industrial and scientific concern, by manufacturing and selling alkaloids.
Merck
44
a biopharma company that has grown from a handful of individual founders into a company of over 69,000 people.
GlaxoSmithKline
45
became involved in the industrial production of medicine, producing patented medicine in 1842, and the world’s first factory for producing only medicines in 1859.
Beecham
46
was founded in 1849 by two German immigrants, initially as a fine chemicals business. – Charles Pfizer & Charles Erhart
Pfizer
47
Their business expanded rapidly during the American Civil War as demand for painkillers and antiseptics rocketed.
Pfizer
48
was providing the medicines needed for the Union war effort,
Whilst Pfizer
49
a young cavalry commander named Colonel Eli Lilly was serving in their army.
Colonel Eli Lilly
50
was an archetype of the dynamic and multi-talented 19th century American industrialist, who after his military career, and trying his hand at farming, set up a pharmaceutical business in 1876. * He was a pioneer of new methods in the industry, being one of the first to focus on R&D as well as manufacturing.
Lilly
51
who as a naval doctor during the Mexican-American war of 1846–1848 threw the drugs he was supplied with overboard due to their low quality.
Edward Robinson Squibb,
52
He set up a laboratory in 1858, like Pfizer supplying Union armies in the civil war, and laying the basis for today’s BMS.
Another military man in the drugs business was Edward Robinson Squibb,
53
Swiss manufacturers gradually began to realise their dyestuffs had antiseptic and other properties and began to market them as pharmaceuticals, in contrast to the origin in pharmacies of other enterprises. * Switzerland’s total lack of patent laws led to it being accused of being a “pirate state” in the German Reichstag.
Sandoz, CIBA-Geigy, and Roche of the pharmaceutical industry all have their roots in this boom.
54
was founded in 1863 as a dye maker in Wuppertal, the hometown of Karl Marx’s collaborator Friedrich Engels.
Bayer
55
It later moved into medicines, commercializing ASPIRIN around the turn of the 20th century, one of the most successful pharmaceuticals ever at that point.
Bayer
56
discovered the first antibiotic, Penicillin. However, it took over a decade before penicillin was introduced as a treatment for bacterial infections
In 1928: Alexander Fleming
57
The first commercially available antibacterial
Prontosil,
58
a sulfonamide developed by the German biochemist Gerhard Domagk
Prontosil,
59
In 1945: Penicillin was introduced on a large scale as a treatment for bacterial infections. This was possible through the work of BLANK Chain who managed to efficiently purify the antibiotic and scale up the production.
Howard Florey and Ernst Boris
60
marked the beginning of the so-called “golden era” of antibiotics
The introduction of penicillin