History of Clinical Research

Question 1

When Walter Cannon proposed that the AMA adopt guidelines for human subjects research, Francis Peabody was opposed because. . .

Answer 1

Peabody worried that if the AMA endorsed a requirement for informed consent for human research, then physicians would be expected (or even required) to obtain informed consent for all diagnostic and therapeutic procedures, something that would disrupt routine clinical care.

Question 2

Clinical equipoise

Answer 2

The genuine uncertainty within the scientific and medical community as to which of two interventions is clinically superior

Question 3

Seven ethical requirements for clinical research

Answer 3

1. Social or scientific value
2. Scientific validity
3. Fair subject selection
4. Favorable risk-benefit ratio
5. Independent review
6. Informed consent
7. Respect for potential and enrolled subjects