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MTAP 2 IMMUNOSEROLOGY > HISTORY > Flashcards

HISTORY Flashcards

1
Q

These people first used Inhalation or Insuffation of dried powders from small pox lesion, which will cause minimal effects when exposed early

A

1500 CHINESE

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2
Q

Smallpox vaccine was first discovered by exposing individuals to cowpox lesion which creates “artificial immunity” or “cross immunity”

A

1798 EDWARD JENNER

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3
Q

Phagocytosis or engulfment of cells was discovered

A

1862 Haeckel

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4
Q

He is the “Father of Immunology”, which discovered the Attenuation of bacteria Pasteurella multocida by the use of Chicken cholera. He also attenuated the vaccine for Rabies.

A

1880-1881 LOUIS PASTEUR

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5
Q

PROCESS OF ATTENUATION

A

HEAT, AGING, CHEMICAL MEANS

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6
Q

1883 Elie Metchinikoff

A

Cellular theory of immunity through Phagocytosis
He discovered the phagocytosis

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7
Q

Humoral Theory of Immunity

A

Emil Von Behring and Kitasata

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8
Q

Type IV Delayed Type Hypersensitivity

A

1891 Robert Koch

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9
Q

Complement mediated cytolysis

A

1894-1895 Pfeiffer and Buchner

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10
Q

Discovery of Agglutination reaction

A

1896 Gruber and Durham

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11
Q

1896 Ferdinand Widal

A

Widal Test, Discovery of agglutination reaction for typhoid fever diagnosis

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12
Q

Antibody formation and Side Chain theory

A

1900 Paul Ehrlich

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13
Q

Discovery of ABO Blood Group

A

1900 Karl Landsteiner

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14
Q

Discovery of the most severe form of hypersensitivity (Type I Immediate hypersensitivity)

A

1902 Portier and Charles Richet

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15
Q

Discovery of Type III Hypersensitivity

A

1903 Arthus

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16
Q

Process by which a particular antigen becomes more susceptible to phagocytosis

A

Opsonization

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17
Q

Discovery of Opsonins

A

1903 Almoth Wright, Stephen Douglas, Joseph Denys

18
Q

1903 George Snell

A

Genetics of the murine MHC Class 1-3

19
Q

Describes the relationship between immunity and hypersensitivity

A

1906 Von Pirquet and Schick

20
Q

1906 Jean Dausset

A

Early pioneer in the study of MHC and HLA

21
Q

Developed the Hemolytic Plaque Assay

A

1911 Niel Jerne

22
Q

Father of Transplantation, and Acquired Immunologic Response

A

1915-1987 Peter Medawar

23
Q

Study of the Complement System

A

1920 Jules Bordet

24
Q

1920 Barui Bernaceraf

A

Discovery of immune response genes and regulation

25
Q

1920-1985 Rodney Porter

A

Discovery of polypeptide structure of Antibody

26
Q

Vaccine against tuberculosis

A

1921 Albert Calmette and Camille Guerin

27
Q

1921 Rosalyn Yalow

A

Developed Radioimmunoassay of peptide hormones

28
Q

Discovery of Penicillin and description of action of lysozymes

A

1922 Alexander Flemming

29
Q

1924 James Gowan

A

Discovered that Adaptive Immunity is mediated by lymphocytes

30
Q

1927 Cesar Milstein and Georges Kohler

A

Developed the technique of monoclonal Antibody formation

31
Q

1929 Gerald Edelman

A

Discovery of immunoglobulin structure and complete sequence of Antibody molecule

32
Q

Discovery of vaccine against Yellow Fever

A

1930 Max Theiler

33
Q

Lattice hypothesis, Antigen-antibody hypothesis

A

1938 Marrack

34
Q

Discovers the Somatic Recombination

A

1939 Susumu Tonegawa

35
Q

Development of Polio Vaccine

A

1949 Salk and Sabin

36
Q

1957 Burnet

A

Clonal Selection Theory, Memory Cell, Plasma Cells, Apoptosis

37
Q

Substance that interfered with viral replication

A

Interferons

38
Q

Discovery of Interferons

A

1957 Alic Isaacs and Jean Lindemann

39
Q

1980 Luc Montaigner

A

Discovery of Lymphadenopathy Associated Virus (LAV)

40
Q

Renamed the retrovirus as Human Immunodeficiency Virus

A

1980 Robert Gallo

41
Q

1986 Mosmann

A

Th1 and Th2 model of T Helper function

42
Q

Factors affecting Innate Immunity

A

Age
Nutrition
Fatigue
Stress
Genetic determinants

MTAP 2 IMMUNOSEROLOGY (9 decks)

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