CYTOKINES

Question 1

Small soluble proteins that regulate the immune system, a class of non antibody molecules. Their action is mediated by binding to specific receptors on target cells

Answer 1

CYTOKINES

Question 2

What are the features of Cytokines

Answer 2

Pleiotropism
Redundancy
Acts in networks
Acts as hematopoietic growth factor

Question 3

Actions of Cytokines

Answer 3

Autocrine Stimulation- affecting same cell secreted
Paracrine- affecting a target cell in close proximity
Endocrine- systemic effect

Question 4

INTERLEUKIN 1B
Secreted by:
Actions:

Answer 4

Secreted by: Monocytes, Macrophages, DCs
Actions: Inflammation, fever, initiation of acute phase response

Question 5

TUMOR NECROSIS FACTOR ALPHA

Secreted by:
Actions:

Answer 5

Secreted by: Monocytes, macrophages, neutrophils, NK cells, Activated T cells
Actions: Inflammation, initiation of acute phase response, death of tumor cells

Question 6

INTERLEUKIN 6

Secreted by:
Actions:

Answer 6

Secreted by: Monocytes, macrophages, endothelial cells, Th2 cells
Actions: Initiation of acute phase response, Activation of B and T cells

Question 7

Transforming growth factor beta

Secreted by:
Actions:

Answer 7

Secreted by: T cells, macrophages
Actions: Inhibition of both T and Cell proliferation, induction of IgA, inhibition of macrophages

Question 8

Interferon-alpha & Interferon-beta

Secreted by:
Actions:

Answer 8

Secreted by: Macrophages, DCs, virally infected cells
Actions: Protects cell against viruses, increases class I MHC expression, NK cell activation