Histology - Midterm Flashcards
The smallest unit of organization in the body
The cell
Each cell has a
Cell membrane
Cytoplasm
Organelles
Inclusions
Cells grouped together with similar characteristics of form and function
Tissue
Various tissue types are bonded together to form a
Organ
Organs that function together form a
System
An active transport of material from a vesicle within the cell out into the extracellular environment.
Exocytosis
The uptake of materials from the extracellular environment into the cell
Endocytosis
Endocytosis can take place as a _______ of the cell membrane, or can also take the form of _________
Invagination or phagocytosis
Engulfing and then digesting of solid waste and foreign material by the cell through enzymatic breakdown of the material
Phagocytosis
_______ surrounds the cell
Cell membrane
Tough and resourceful gatekeeper for the cell’s interior
Cell membrane
The usual cell membrane is in intricate bilayer, consisting mostly of _________ & _______
Phospholipids and proteins
________ serve mostly as a difussion regulator
Phospholipids
The _______ of the cell membrane serves as structural reinforcements as well as receptors for specific hormones, neurotransmitters, and antibodies.
Proteins
The ______ includes the semifluid part contained within the cell membrane boundary as well as the skeletal system of support or cytoskeleton
Cytoplasm
Spaces or cavities within the cytoplasm
Vacuoles
Metabolically active specialized structures within the cell
Organelles
_______ allow each cell to function according to its genetic code.
Organelles
What are the 7 major organelles of the cell
- Nucleus
- Mitochondria
- Ribosomes
- Endoplasmic reticulum
- Golgi apparatus
- Lysosomes
- Cytoskeleton
The largest, most dense, and most conspicuous organelle in the cell when it is examined microscopically.
Nucleus
A nucleus is found in all cells of the body except _________.
Mature red blood cells
Most cells in the body are
A) multinucleated
B) binucleated
B) binucleated
The main nucleic acid in the nucleous is ______ in the form of ________.
DNA in the form of Chromatin
_______ is a complex of DNA & protein
Chromatin
In an actively dividing cell, the chromatin condenses into a visible and discrete rod like ______.
Chromosomes
Each chromosome has a _____, a clear constricted area near the middle.
Centromere
Chromosomes become two filamentous or threadlike ________ as daughter chromosomes joined by a centromere during cell division
Chromatid
Command center of the cell
Nucleus
The nucleus is surrounded by the ________ a membrane similar to the cell membrane, except that it is double layered.
Nuclear envelope
Contained in the nucleus is the
Nucleolus
The nucleolus mostly produces
rRNA
rRNA
Ribosomal RNA
mRNA
Messenger RNA
tRNA
Transfer RNA
Without a ______, no protein synthetic activity would occur within the cell.
Nucleolus
______ are the most numerous organelles of the cell
Mitochondria
Powerhouse of the cell
Mitochondria
_______ is a major source of ATP
Mitochondria
Most of the cell’s energy comes from the ______
Mitochondria
Stage in the life cycle when a cell grows
and forms new organelles
A) interphase
B) prophase
C) metaphase
D) anaphase
E) telophase
Interphase
______ consists of 3 phases : G1, S, & G2
A) interphase
B) prophase
C) metaphase
D) anaphase
E) telophase
Interphase
Continuous process during which the nuclear parts of a cell are divided into two equal daughter cells
Mitosis
Nuclear membrane and
nucleolus disappear.
A) interphase
B) prophase
C) metaphase
D) anaphase
E) telophase
Prophase
Chromosomes align at the equator of the spindle
A) interphase
B) prophase
C) metaphase
D) anaphase
E) telophase
Metaphase
Centromeres split, and each chromosome
separates into 2 chromatids.
Chromatids migrate to opposite poles by the
mitotic spindle
A) interphase
B) prophase
C) metaphase
D) anaphase
E) telophase
Anaphase
Division into 2 daughter cells.
Nucleoli appear. Microtubules disappear
A) interphase
B) prophase
C) metaphase
D) anaphase
E) telophase
Telophase
Process by which all cytoplasmic components of the cell are divided into two identical daughter cells following mitosis.
Cytokinesis/ cytoplasmic division
_______ is the process by which a less specialized cell becomes a more specialized cell type.
Differentiation
Life cycle of a cell
- Interphase (DNA replication)
- Mitosis (Cell Division)
- Cytokinesis (Cytoplasmic Division)
- Differentiation
Tiny sphere shaped organelles in the cell
Ribosomes
Protein factories
Ribosomes
Primary function:
modification, storage, segregation, and transport of proteins that the cell manufactures.
Endoplasmic Reticulum
________ consists of parallel membrane-bound channels.
Endoplasmic Reticulum ER
Highway system of the cell
Endoplasmic Reticulum
Contains ribosomes on its outer surface
Rough ER
Particles composed of protein and RNA, which synthesizes protein
Ribosomes
No ribosomes
Smooth ER
This organelle contains enzymes involved in manufacturing various lipid molecules and steroid hormones
Smooth ER
“Chemical processing and packaging center”
Golgi apparatus
The second largest organelle
Golgi apparatus
Function: sorts, condenses, packages, and delivers proteins from the RER.
Golgi apparatus
Attached to the cell’s membrane and release its contents by exocytosis
Golgi apparatus
“Powerhouse” of the cell
Mitochondria
The inner membrane of the mitochondria is folded to increase in surface area forming _____.
cristae
Most numerous organelle in the cell
Mitochondria
Releases energy from food molecules and transforms energy into ATP
Mitochondria
The golgi apparatus not only prepares proteins for export by exocytosis but also produces a second organelle ___________
Lysozome
Organelles produced by the golgi apparatus and extracellular digestion by the cell
Lysosomes
“Sewer system” of the cell
Lysosomes
Membranous sacks produced by the Golgi
Apparatus.
Lysosomes
Contains hydrolytic (hyaluronidase) and
digestive enzymes capable of digesting substances that enter cells.
Lysosomes
The ___________ compartmentalizes
(sorts out) the cytoplasm, creating preferred
“freeways” for the movement of molecules
formed by cellular processes.
Cytoskeleton
Components of the _______ give basic stability to the cell as a whole, functioning like reinforced girders.
Cytoskeleton
3 components of the cytoskeleton
–microfilaments
–intermediate filaments
–microtubules
Delicate, threadlike, microscopic structures of
specialized protein, arranged in meshwork of bundles.
A) microfilaments
B) intermediate filaments
C) microtubules
Microfilaments
Cause various kinds of cellular movements
A) microfilaments
B) intermediate filaments
C) microtubules
Microfilaments
Responsible for cell motility
A) microfilaments
B) intermediate filaments
C) microtubules
Microfilaments
Long slender tubes with diameters 2 or 3 times greater than microfilaments.
A) microfilaments
B) intermediate filaments
C) microtubules
Microtubules
maintain the shape of the cell.
A) microfilaments
B) intermediate filaments
C) microtubules
Microtubules
Provides strength to the structure of:
– cilia (shorter, many)
– flagella (longer, few)
– centrioles
– mitotic spindle
A) microfilaments
B) intermediate filaments
C) microtubules
Microtubules
Various types of thicker, threadlike microscopic structures within the cell.
A) microfilaments
B) intermediate filaments
C) microtubules
Intermediate filaments
important in intercellular junctions
Intermediate filaments - Tonofilaments
Metabolically inert substances that are transient over time in the cell.
Inclusions
Closes intercellular space between cells by
fusing cell membranes together
A) Tight junctions
B) Gap junction
Tight junctions
Prevents the movement or loss of fluid.
A) Tight junctions
B) Gap junction
Tight junctions
Form tubular channels between cells that allow substances to be exchanged
A) Tight junctions
B) Gap junctions
Gap junctions
Bind cells together by creating “spot welds”
between adjacent membranes.
a) desmosomes
B) hemidesmosomes
Desmosomes
Attachment of cell to an adjacent
non-cellular surface.
a) desmosomes
B) hemidesmosomes
Hemidesmosomes
Used in attachment of epithelium to connective tissue
a) desmosomes
B) hemidesmosomes
Hemidesmosomes
Allows gingival tissue to adhere to the tooth surface by epithelial attachment.
a) desmosomes
B) hemidesmosomes
Hemidesmosomes
______ is the tissue that covers and lines external and internal body surfaces, including vessels & small cavities.
A) epithelial
B) connective
C) Muscle
D) Nerve
Epithelial
______ tissue serves as a protective covering as well as tissue absorption, secretion, sensory, and other specialized functions
A) epithelial
B) connective
C) Muscle
D) Nerve
Epithelial
Study of the microscopic structure
and function of tissues
Histology
Protects complex inner structures from:
- physical, chemical, and pathogenic attacks
- dehydration
- heat loss
A) epithelial
B) connective
C) Muscle
D) Nerve
Epithelial
T/F: Depending on individual classification, epithelial tissue can be derived from any of the three embryonic cell layers based on the location when developing.
True
Both the epithelium of the skin and that of the oral mucosa are of similar _________ origin.
A) Ectoderm
B) Mesoderm
C) Endoderm
Ectoderm
respiratory and digestive tract
A) Ectoderm
B) Mesoderm
C) Endoderm
Endoderm
urinary tract
A) Ectoderm
B) Mesoderm
C) Endoderm
Mesoderm
Cells packed closely together; surrounded by very little or no intercellular substance or tissue fluid.
A) epithelial
B) connective
C) Muscle
D) Nerve
Epithelial
Avascular; no blood supply of its own
A) epithelial
B) connective
C) Muscle
D) Nerve
Epithelial tissue
How does epithelium receive cellular nutrition
obtained by diffusion from the connective tissue
Epithelial cells are: tightly joined together by:
Desmosomes
Epithelial cells are: joined to basement
membrane by
Hemidesmosomes
Label 1
Connective tissue
Label 2
Basil lamina
Label 3
Hemidesmisome
Label 4
Epithelial cells
Label 5
Desmosome
Simple epithelium consists of a
Single layer of epithelium
Endothelium
This simple squamous epithelium lining of vessels and serous cavities (surround organs) is called
Endothelium
Simple squamous
Simple cuboidal
Simple columnar
Transitional relaxed
Transitional stretched
Stratified squamous
Pseudostratified
Cells are flat, arranged in one layer
Simple squamous
Be proud of yourself
It will all pay off.
These epithelial cells cover connective tissue & and perform a filtering function
Simple squamous
Lungs, inner & middle ear, blood and lymphatic vessels , heart & serous cavities are locations of what epithelium
Simple squamous
Contributes to secretion & protective covering of an organ
- Simple Squamous
- Simple Cuboidal
- Simple Columnar: Ciliated or non-ciliated
- Pdeudostratified
Simple cuboidal
Cube-like cells; Nucleus is in the center
of the cell
- Simple Squamous
- Simple Cuboidal
- Simple Columnar: Ciliated or non-ciliated
- Pdeudostratified
Simple cuboidal
These cells line the ducts of various glands, such as ducts of the salivary glands
- Simple Squamous
- Simple Cuboidal
- Simple Columnar: Ciliated or non-ciliated
- Pdeudostratified
Simple cuboidal
Function:
protection, secretion/absorption due to
goblet cells
- Simple Squamous
- Simple Cuboidal
- Simple Columnar: Ciliated or non-ciliated
- Pdeudostratified
Simple columnar
T/F: Simple columnar epithelium may be ciliated
True
The following are locations of what type of epithelium
- Stomach
- Large/small intestine
- Lining of cervical canal
- Simple Squamous
- Simple Cuboidal
- Simple Columnar: Ciliated
- Simple Columnar: non-ciliated
- Pdeudostratified
Simple columnar: non-ciliated
The following are locations of what type of epithelium
- uterus
- fallopian tubes
- ductus deferens (male reproductive)
- small intra-pulmonary bronchi (lungs)
- Simple Squamous
- Simple Cuboidal
- Simple Columnar: Ciliated
- Simple Columnar: non-ciliated
- Pdeudostratified
Simple columnar: Ciliated
Crowded columnar cells; Nuclei are at different levels.
Pseudostratified columnar epithelium
This epithelium moistens, warms, and cleans lining membranes.
Pseudostratified columnar epithelium
T/F: Pseudostratified columnar
epithelium may be ciliated or non-ciliated
True
The following are locations of what type of epithelium
-Upper respiratory tract including
nasal cavity and paranasal
sinuses
Pseudostratified columnar epithelium
Many layers of cells on an irregular
basal layer with no layer of keratin.
Stratified squamous NON-keratinized epithelium
7 Locations of Stratified squamous NON-keratinized epithelium
- Buccal and alveolar mucosa
- Ventral of tongue
- Soft palate
- Floor of the mouth
- Sulcular epithelium
- Esophagus
- Cornea
This type of epithelium is located on dry or wet surfaces.Has a keratin layer for protection
Stratified squamous keratinized epithelium
Stratified squamous keratinized epithelium is composed of what 5 layers
(bae said grandma loved cuddling)
- Stratum basale
- Stratum spinosum
- Stratum granulosum
- Stratum lucidum
- Stratum corneum
6 Locations of Stratified squamous Keratinized epithelium
- Skin
- Free gingiva (outside only)
- Attached gingiva
- Hard palate
- Dorsal side of tongue
- Lips
Label 1
Hypodermis
Label 2
Dermis
Label 3
Epidermis
Label 4
Stratum corneum
Label 5
Stratum granulosum
Label 6
Stratum sponosum
Label 7
Stratum basale
Shape of the surface cells changes depending on the degree of stretch in this epithelium
Transitional epithelium
Cells are soft, pliable, and loosely arranged in this epithelium
Transitional epithelium
Location of transitional epithelium
Urinary bladder
Thin, acellular structure.
Located between the epithelium and connective tissue
Basement membrane
T/F: Transitional epithelium ranges between stratified squamous
non-keratinized and stratified columnar epithelium
True
What 3 layers make up the basement membrane?
- Lamina lucida
- Lamina densa
- Reticular lamina
What 2 layers make up the basal lamina
- Lamina lucida
- Lamina densa
Label a
Tonofilaments
Label b
Hemidesmosome
Label c
Lamina lucida
Label d
Lamina densa
Label e
Basement membrane
Label f
Basal lamina
Label g
Reticular lamina
Label h
Connective tissue
Label i
Epithelium
3 Major cells of connective tissue
- Fibroblasts
- Macrophages (monocytes)
- Mast cells (basophils)