Histo - neuroonc

Question 1

NF2 (neurofibromatosis type II)

Seizure symptoms

Answer 1

meningioma

Question 2

A malignant, invasive embryonal tumour of the cerebellum, seen in children, mainly neuronal differentiation and a tendency to metastasise via CSF pathway

Answer 2

Medulloblastoma

‘YOUNG AND MALIGNANT’

Question 3

Young person, cystic, indolent

Rosenthal fibres
Granular bodies
Piloid “hairy” cell

Answer 3

Pilocytic astrocytoma

Pilo is indolent, medullo is invasive!

‘YOUNG’ and ‘INDOLENT’

Question 4

Grading says you are dead in a year. What grade is this?

Answer 4

IV

Grade I - Long term survival/cured

Grade II - Death in >5y

Grade III - Death <5y

Grade IV - Death 6 months - 1y

Question 5

Soft, gelatinous, calcified

IDH1, Frontal lobe in 50-60% of cases

Long history of neurological signs (seizures more frequent)

Answer 5

Oligodendroma

Better prognosis than astrocytoma

‘CALCIFIED’

Question 6

Ventricular tumour, hydrocephalus, visual loss due to pap oedema

Answer 6

Ependymoma

FLUID

Age peaks at 5 and 35

Question 7

Most common glial, diffuse, swollen, fibrillary

Answer 7

Diffuse astrocytoma

Everywhere
80% of gliomas

Question 8

Most aggressive glial tumour

Answer 8

Glioblastoma