Chem Path - Liver

Question 1

Megamitochondria sign in liver

what is this a sign of?

Answer 1

Cirrhosis

Question 2

Liver biopsy results

Fatty droplets

Answer 2

NASH

Non alcoholic fatty liver disease

Question 3

Liver biopsy results

Mallory-Denk Bodies

Answer 3

Alcoholic liver disease

Question 4

Liver biopsy results

Ballooning

Answer 4

Hepatocyte death - usually Fatty liver but can still be hepatitis

Question 5

Liver biopsy results

Neutrophil infiltration

Answer 5

Hepatocyte injury, causing inflammation

Question 6

Liver biopsy results

Lymphocyte infiltration

Answer 6

Viral Hepatitis

Question 7

How bad is this liver?

Spider naevae 

Palmar Erythema 

Dupytren's contractures 

Gynaecomastia

Answer 7

Chronic Stable Liver Disease

Less able to perform normal functions such as oestrogen clearance. But no signs yet of extra hepatic shunting

Question 8

How bad is this liver?

Caput medusae
Splenomegaly
Ascites

Answer 8

Bad - Portal hypertension

Caput medusae

    Pressure in the umbilical vein due to portosystemic shunting 

Splenomegaly

    Backing up of blood into the spleen (can't get through liver) 

Ascites

However, not completely awful, at least toxins are still being cleared.

Question 9

How bad is this liver?

Liver flap

Answer 9

V. Bad

Ammonia not being cleared, causing a liver flap.

At this point, can’t make albumin or clotting factors - not good.