Histo Lec M4 - Epithelial Tissues Flashcards
is a group of connected cells from the same origin that have a similar function within an organism.
tissue
form the boundary between external environment and body tissues. They cover body surfaces (e.g., the epidermis of the skin) and line the lumens of internal organs that open to the exterior of the body.
Epithelial tissues
composed of a basal lamina and a reticular lamina
The basement membrane
by the epithelial cells and consists of the lamina lucida and the lamina densa.
basal lamina
secreted by fibroblasts located in the underlying connective tissue.
reticular lamina
Functions of the basement membrane
- Provides support and attachment for the epithelial cells
- Selective diffusion barrier
Cells are much wider than tall, resembling a “fried egg.” Nucleus is highly flattened.
Squamous
Cells are of equal height and width.
2.
Nucleus is spherical.
Cuboidal
Cells are much taller than they are wide.
2.
Nucleus is oval shaped, generally located toward the base of the cell.
Columnar
One cell layer thick.
2.
All cells rest on the basement membrane (basal surface) and all cells face the free surface.
Simple epithelium
Cells are of various heights. All cells rest on the basement membrane, but only the tallest cells reach the free surface. Variation in height of the cells and the location of nuclei give the appearance of a stratified epithelium. Frequently ciliated.
Pseudostratified (One cell layer thick)
More than one cell layer thick.
2.
Only the deepest layer of cells has contact the basement membrane and only the superficial‐most cells have a free surface.
Stratified epithelium
Protects from physical abrasion and prevents desiccation
Stratified squamous
Lining of wet cavities, including the mouth, esophagus, rectum, and anal canal; surface cells are nucleated and living.
Nonkeratinized (moist).
Epidermis of the skin; surface cells are nonliving
Keratinized
Lines the larger ducts of exocrine glands
Stratified cuboidal/columnar
Protective function; constructed to expand with distension of the hollow organs it lines. Unique to the urinary system; lines the urinary bladder and ureter
Transitional
Large, nonmotile; not cilia Contain a core of actin microfilaments
Present on cells lining the epididymis and ductus deferens in the male reproductive tract
Stereocilia
Finger‐like extensions from the free surface of the cell, about 1 micron in height Are present in large numbers on each cell and, collectively, are called a brush or striated border
Prominent on cells lining the digestive tract and proximal tubules in the kidney
Microvilli
Multiple hair‐like extensions from free surface of the cell; 7–10 microns in height. Highly motile; beat in a wave‐like motion
(e.g., in the respiratory system and the oviduct of the female reproductive system)
Cilia
Specialized structures of the plasma membrane that:
* Attach and anchor cells
* Establish apical and basolateral membrane domains by sealing adjacent plasma membranes
* Provide channels for ionic and metabolic coupling
Cell Junctions
Belt‐like, barrier junction around apex of the cell
* Provides close apposition of adjacent plasma membranes and occludes the intercellular space
Tight junction (zonula occludens)
Prevents diffusion of material between the intercellular space and the lumen of the organ
*
Establishes apical and basolateral membrane domains in the cell by preventing the lateral migration of proteins in plasma membrane
Tight junction
Attach cells to each other and anchor them to the basal lamina; no fusion of the plasma membrane
Adherent junctions
junction that encircles the apex of the cell like a barrel strap and is located immediately beneath the zonula occludens; serves to attach adjacent cells together; associated with actin filaments.
Belt desmosome (zonula adherens
Disk‐like junctions scattered over the surface of the cell, which are paired with similar structures in adjacent cells; associated with intermediate filaments (e.g., keratin filaments in epithelial cells).
Spot desmosome (macula adherens).
Represent a “half desmosome”; these junctions anchor the basal surface of the cell to basal lamina
Hemidesmosome
Consists of the zonula occludens, zonula adherens, and desmosomes; because these structures cannot be resolved as separate structures at the light microscopic level, they appear as a single, bar‐ shaped, dark region at the apical corners of adjacent cells
Junctional complex
consist of connexons (also known as a connexin hemichannel), six transmembrane proteins clustered in a rosette that defines a central pore.
Gap junction.