Histo Connective Tissue

Question 1

CT tissue cells are separated from each other by _____

Answer 1

ECM

Question 2

Embryonic Connective Tissue contains ____ ___ ___

Answer 2

Pluripotent Stem cells

Question 3

What are the 2 main types of Adult CT?

What are the subtypes for each one?

Answer 3

Fibrous CT:

Loose (Areolar)

Dense Regular- tendons connecting skeletal muscle to bone

Dense Irregular- fibers are deposited in a random pattern, Ex. Dermis of the skin

Special CT:

Adipose

Bone

Cartilage

Hematopoietic

Question 4

What are the 6 cells of connective tissues and what are each of their functions?

Answer 4

Fibroblasts- produce collagens, proteoglycans, and glycoproteins

Mesenchymal cells- connective tisseu stem cells

Adipocytes- store and release fats

Chondrocytes- produce and maintain cartilage components

Osteoblasts- produce bone

Hematopoietic stem cells- produce rbcs and immune cells (Macrophages, mast cells, lymphocytes, plasma cells)

Question 5

What is the function of Collagen? What is the most common type?

Answer 5

Resist tension

Type I is the most common

Question 6

What si the function of Elastin?

What 3 cells does it promote the assembly of?

Answer 6

Stretchable

Assembly of Tropoelastin, Fibulin-1, and Fibrillins 1/2

Question 7

What is the function of Reticular Fibers?

Answer 7

Forms a supportive meshwork

Question 8

What is deficient is patients suffering from scurvy? Why is this important?

Answer 8

Vitamin C deficiency, which is a co-factor in cross-linking collagen fibers, therefore weakening the connective tissue

Question 9

What is the issue with Ehlers-Danlos Syndrome?

Answer 9

Abnormal collagen synthesis leads to weakening of collagen fibers

Question 10

What is Embryonic Connective Tissue also known as in the umbilical cord?

Answer 10

Wharton’s Jelly

Question 11

What is Embryonic Connective Tissue rich in?

Answer 11

Mesenchymal stem cells (multipotent)

Question 12

What are the 5 types of tissues that Adult Mesenchymal stem cells can differentiate into?

Answer 12

Fibroblasts

Muscle cells (skeletal and smooth)

Osteoblasts

Chondroblasts

Adipocytes

Question 13

What are the 2 types of fat?

Answer 13

White Fat- Energy storage, insulation, hormone secretion

Brown Fat- thermogenic tissue, abundant in newborns

Question 14

What are the 4 locations of Dense Regular CT?

Is Dense Regulat CT vascularized?

Answer 14

Tendons

Ligaments

Aponeuroses

Joint Capsules

*No it is not well vascularized

Question 15

Where are 3 places Elastic CT is found?

Answer 15

Walls of blood vessels

Brionchioel tubes

Ligamentum Nuchae

Question 16

What is defective in patients suffering from Marfan’s Syndrome?

Answer 16

Elastin is weakened due to a mutation in Fibrillin-I gene, which is a component of Elastin Fibers

Patients tend to be tall with long arms/legs

Question 17

What do Plasma cells different from?

What is their function?

Answer 17

B-lymphocytes

Function is to produce antibodies

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