His: Bones and Cartilage

Question 1

no active matrix production

Answer 1

zone of reserve cartilage

Question 2

cartilage cells undergo division and organize into distinct columns (actively produce types I and II collagen & other matrix proteins)

Answer 2

zone of proliferation

Question 3

greatly enlarge chondrocytes with clear cytoplasm; secrete factors that initiate vascular invasion

Answer 3

zone of hypertrophy

Question 4

• hypertrophied cells begin to degenerate and cartilage matrix becomes calcified
• serves as initial scaffold for deposition of new bone

Answer 4

zone of calcified cartilage

Question 5

• nearest the diaphysis
  
  • calcified cartilage is in direct contact with marrow cavity
  • blood vessels and osteoprogenitos invade the region
  • osteoprogenitor cells will diferentiate into osteoblasts

Answer 5

zone of ossification/resorption