High Risk Drugs: Ranges

Question 1

Carbamazepine

Answer 1

4-12 mg/L

1- 2 weeks

Question 2

Digoxin

Answer 2

0.8- 2 ng/ml

at least 6 hours after a dose.

The plasma concentration alone cannot indicate toxicity reliably, but the likelihood of toxicity increases progressively through the range 1.5 to 3 micrograms/litre for digoxin

Question 3

Lithium

Answer 3

0.4- 1 mmol/ L

0.8–1 mmol/litre is recommended for acute episodes of mania, and for patients who have previously relapsed or have sub-syndromal symptoms

12 hours after the dose

Question 4

Phenobarbital

Answer 4

15- 40mg/ L

Question 5

Phenytoin

Answer 5

10- 20mg/ L

all ‘phs’ are 10-20

Question 6

Theophylline

Answer 6

10-20 mg/L after 4-6 hours

all ‘phs’ are 10-20

Question 7

Aminophylline

Answer 7

10- 20 mg/L