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Pre-Registration Pharmacy > High Risk Drugs > Flashcards

High Risk Drugs Flashcards

1
Q

What drug class is Methotrexate?

A

Disease modifying anti-rheumatic drug

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2
Q

What strength do methotrexate tablets come in?

A

2.5mg

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3
Q

What is the never event associated with methotrexate?

A

overdose in non-cancer indications

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4
Q

What are the main (high concern) side effects of methotrexate?

A

Liver cirrhosis
Pulmonary fibrosis
Bone marrow suppression
Mucosal damage

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5
Q

What are the common side effects of methotrexate?

A

Headache
Fatigue
Nausea
Increased risk of infection
Thrombocytopenia

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6
Q

What is Methotrexate indicated for?

A

Rheumatoid arthritis
Psoriasis and psoriatic arthritis
Chemotherapy

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7
Q

What is the MHRA warning for Methotrexate?

A

Once weekly dosing

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8
Q

What advice should be offered for methotrexate in pregnancy?

A

Methotrexate is teratogenic and should be avoided in pregnancy. Contraception should be used during treatment and for 3 months after.

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9
Q

What are the 5 forms of insulin?

A

Rapid-acting
Short-acting
Intermediate-acting
Long-acting
Biphasic

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10
Q

What type of insulin is insulin aspart?

A

Rapid -acting

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11
Q

What type of insulin is soluble insulin?

A

Short-acting

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12
Q

What type of insulin is isophane insulin?

A

Intermediate-acting

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13
Q

What type of insulin is insulin glargine?

A

Long-acting

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14
Q

What type of insulin is insulin detemir?

A

Long-acting

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15
Q

Which types of insulin are in a biphasic insulin preparation?

A

Short and intermediate

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16
Q

How in insulin excreted?

A

Renally

17
Q

What are the 3 types of insulin regimen for Type 1 diabetes?

A

Basal-bolus
Biphasic
Continuous

18
Q

What are the 3 types of insulin regimen for Type 2 diabetes?

A

Intermediate-acting twice daily
Long-acting once a day
Basal-bolus
Biphasic

19
Q

What do you need to be aware of with concurrent systemic steroid use with insulin?

A

Concurrent steroid use will increase insulin requirements

20
Q

What monitoring needs to be performed before initiation of methotrexate?

A

FBC
LFTs
U&Es

Pre-Registration Pharmacy (20 decks)

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