Herpesviridae

Question 1

Morphology of herpesviridae?

Answer 1

• spherical to pleomorphic
• layer of globular material known as tegument
• enveloped
• dsDNA genome

Question 2

Where does viral replication occur for Herpesviridae viruses?

Answer 2

nucleus

Question 3

How do herpes viruses acquire their envelope?

Answer 3

Budding through the inner layer of the nuclear envelope

Question 4

How are herpes virions released?

Answer 4

Exocytosis or cytolysis

Question 5

___________ promotes extended survival of herpesviruses

Answer 5

Moist, cool environments

Question 6

__________ serve as a reservoir for transmission of herpesviruses

Answer 6

latently infected animals

Question 7

_________ infection with periodic or continuous shedding occurs in all herpesvirus infection

Answer 7

Persistent

Question 8

How is a latent herpesvirus infection reactivated?

Answer 8

Stress, shipping, cold, crowding, glucocorticoids (immunosupression)

Question 9

__________ inclusion bodies are characteristic of herpesviruses

Answer 9

Eosinophlic intranuclear, Cowdry type A

Question 10

Herpes viruses are involved in cell fusion, resulting in formation of _______________

Answer 10

syncytium

Question 11

Subfamily of herpesviridae?

Answer 11

1. Alphaherpesvirinae
2. Betaherpesvirinae
3. Gammaherpesvirinae

Question 12

Properties of alphaherpesvirinae subfamily?

Answer 12

1. Highly cytopathic in cell culture
2. Short replication cycle
3. Most are host restricted

Question 13

Most alphaherpesvirinae are highly restricted in their natural host range except ____________

Answer 13

Pseudorabies (suid herpesvirus 1) - broad host range

Question 14

Where do alphaherpesvirinae lesions develop?

Answer 14

Skin or mucosa of resp and genital tracts

Question 15

Bovine Herpesvirus 1 is in the ________ subfamily and causes ________ disease

Answer 15

alphaherpesvirinae,

1. Infectious bovine rhinotracheitis
2. Infectious pustular vulvovaginitis
3. Infectious balanoposthitis
4. Abortion

Question 16

Bovine Herpesvirus 2 is in the ________ subfamily and causes ________ disease

Answer 16

alphaherpesvirinae,

1. Bovine mammilitis
2. Pseudo-lumpy skin disease

Question 17

Equine Herpesvirus 1 is in the ________ subfamily and causes ________ disease

Answer 17

alphaherpesvirinae,

1. Abortion
2. Respiratory disease
3. Encephalitis
4. Perinatal foal mortality

Question 18

Equine Herpesvirus 4 is in the ________ subfamily and causes ________ disease

Answer 18

alphaherpesvirinae, Rhinopneumonitis

Question 19

Porcine Herpesvirus 1 is in the ________ subfamily and causes ________ disease

Answer 19

alphaherpesvirinae,

1. Pseudorabies
2. Aujeszky’s disease

Question 20

Feline Herpesvirus 1 is in the ________ subfamily and causes ________ disease

Answer 20

alphaherpesvirinae, Feline viral rhinotracheitis

Question 21

Canine Herpesvirus 1 is in the ________ subfamily and causes ________ disease

Answer 21

alphaherpesvirinae, Hemorrhagic disease in puppies

Question 22

Gallid Herpesvirus 1 is in the ________ subfamily and causes ________ disease

Answer 22

alphaherpesvirinae, Infectious laryngotracheitis of chickens

Question 23

Gallid Herpesvirus 2 is in the ________ subfamily and causes ________ disease

Answer 23

alphaherpesvirinae, Marek’s disease of chickens (Serotype 1)