Circoviridae

Question 1

Circoviridae replication occurs in _________

Answer 1

Actively dividing cells

Question 2

True or False: circoviridae is unstable in the environment

Answer 2

FALSE - very stable

Question 3

Post weaning multisystemic wasting syndrome (PMWS) is caused by __________

Answer 3

Porcine circovirus 2 (PCV2)

Question 4

Who is most at risk for PMWS?

Answer 4

Piglets 4-6 weeks old or 2-3 weeks after weaning

Question 5

__________ is the most common method of spread for PMWS

Answer 5

Fecal-oral

Question 6

How can PMWS be transmitted?

Answer 6

1. Fecal oral most common
2. Vertical transmission (transplacental)
3. Survives on fomites for long periods of time

Question 7

What is seen on histology of PMWS?

Answer 7

Botryoid, grape like intra-cytoplasmic inclusion bodies in virus infected macrophages

Question 8

Pathogenesis of PMWS?

Answer 8

1. Granulomatous inflammation in lymphoid tissues, lungs, liver, kidney, heart, and intestines
2. Lymphoid depletion / Lymphopenia
3. Transplacental infection

Question 9

Transplacental infection of PMWS in a pregnant sow in the last trimester will result in _________

Answer 9

minimal effect on the fetus

Question 10

Transplacental infection of PMWS in a pregnant sow in the first or second trimester results in________

Answer 10

fetal death or aborted fetus with severe cardiac congestion

Question 11

CS associated with PMWS?

Answer 11

1. Weight loss
2. Cough
3. Lymphadenopathy
4. Chronic diarrhea
5. Skin discoloration

Question 12

Co-infection of PMWS with ____________ may cause severe disease and more pronounced lesions

Answer 12

1. Porcine parvovirus
2. Procine repro and resp virus
3. SIV
4. Mycoplasma hyopneumoniae