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Sem 3: Viro > Family: Poxviridae > Flashcards

Family: Poxviridae Flashcards

1
Q

Where does replication of poxviruses occur?

A

Cytoplasm

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2
Q

Most enveloped viruses do not survive well in the environment, which viruses are an exception?

A

Poxvirus

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3
Q

Subfamily ___________ is a poxvirus that infects vertebrates

A

Chordopoxvirinae

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4
Q

Genus of poxvirus that cause disease in humans, animals, and birds? (6)

A
  1. Orthopoxvirus
  2. Parapoxvirus
  3. Avipoxvirus
  4. Capripoxvirus
  5. Leporipoxvirus
  6. Suipoxvirus
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5
Q

Most poxvirus are ______ shaped

A

Brick

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6
Q

What genus of poxvirus is not brick shaped?

A

Genus Parapoxvirus - ovoid with crisscross pattern

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7
Q

Properties of poxvirus:

A

-linear double stranded DNA
-pleomorphic
-largest virus
-sometimes enveloped
-complex symmetry
-dumbbell shaped core, 2 lateral bodies

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8
Q

Two distinct infectious poxvirus particles exist:

A
  1. Intracellular mature virus (IMV) - non enveloped
  2. Extracellular enveloped virus (EEV)

BOTH FORMS ARE INFECTIOUS

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9
Q

How are IMV poxvirus virions released?

A

Disruption of host cell, cell lysis

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10
Q

How are EEV poxvirus virions released?

A

Budding

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11
Q

Which of the following poxviruses do not multiply in chicken embryo?

A. Orthopoxvirus
B. Parapoxvirus
C. Capripoxvirus
D. Avipoxvirus

A

B. Parapoxvirus

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12
Q

Milkers nodule in humans is caused by ______________

A

Pseudocowpox

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13
Q

Pseudocowpox is a member of the genus ___________

A

Parapoxvirus

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14
Q

How is pseudocowpox transmitted?

A

-Contaminated milkers hands, teat cups

-Insects

-Calves suckling on infected teats

-Semen of bulls

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15
Q

Hyperplasia of squamous epithelium describes the pathogenesis of ________

A

Pseudocowpox

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16
Q

CS associated with pseudocowpox?

A

Erythema - Papule - Vesicle or pustule - Rupture - Thick scab

-papule on teat

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17
Q

Chronic lesions of pseudocowpox?

A

-Erythema

-Yellow-gray, soft scabs that are rubbed off during milking

-No pain

-Persists for months

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18
Q

Acute lesions of pseudocowpox?

A

Thick elevated scab 0.5-25 cm

Horse-shoe shaped ring of small scabs on teats after original scab drops off

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19
Q

___________ is a pathognomonic lesion of pseudocowpox

A

Horseshoe-shaped ring like lesion

20
Q

Pseudocowpox in humans results in a mild skin lesion known as ___________

A

Milkers nodule

21
Q

Contagious ecthyma is caused by ________ virus

A

Orf virus in genus parapoxvirus

22
Q

Orf virus causes contagious ecthyma in what hosts?

A

Sheep and goats, mainly babies

23
Q

_______ virus involves a delayed hypersensitivity reaction

A

Orf virus

(contagious ecthyma)

24
Q

What are the first lesions to develop in contagious ecthyma?

A

Mucocutaneous junction accompanied by swollen lips

25
Q

Goats and sheep with Orf virus can have anorexia and weight loss. Why?

A

Lesions around mouth and nose make it hard to eat :(

26
Q

Severe cases of contagious ecthyma can cause lesions where?

A

Genitals, feet, ears

can lead to lameness and infertility

27
Q

When should the Orf virus vaccine be used?

A
  • Lambs and kids in problem herd/flocks
  • Pregnant ewes before lambing

not for prophylactic use

28
Q

What indicates the viability of the Orf virus vaccine when given to sheep and goats?

A

Localized red lesion on inner thigh, 1 week after vaccination

29
Q

CS of Orf virus in humans?

A

Macro-papular lesions and large nodular lesions on hands, arm, face, and even penis

30
Q

Lumpy skin disease is a result of __________ genus

A

Capripoxvirus

31
Q

Sheeppox and Goatpox is caused by members of the __________ genus

A

Capripoxvirus

32
Q

________ and ________ cannot be distinguished from each other with serological techniques

A

Sheeppox and Goatpox

33
Q

Which capripoxvirus does not cause disease in sheep and goats?

A

Lumpy skin disease

34
Q

How is sheeppox and goatpox transmitted?

A

Aerosol - respiratory route most common

35
Q

Swinepox is caused by a member of the _______ genus

A

Suipoxvirus

36
Q

Mechanical vector associated with swinepox transmission?

A

Pig louse - hematopinus suis

37
Q

Fowl pox is caused by a member in the ________ genus

A

Avipoxvirus

38
Q

How is fowlpox transmitted?

A

Wounds in birds from fighting/pecking

Possibly by aerosols

39
Q

What forms of disease are associated with fowl pox?

A
  1. Cutaneous (dry) form
  2. Diphtheritic (wet) form - high fatality
  3. Ocular form
40
Q

What is the most common form of fowlpox?

A

Cutaneous dry form

41
Q

_________ form of fowlpox causes a sharp fall in egg production

A

Cutaneous dry form

42
Q

Which form of fowlpox has a poor prognosis?

A

Diphtheritic wet form

death by asphyxiation

43
Q

CS associated with the ocular form of fowlpox?

A

Conjunctivitis, cheesy exudate under eyes

44
Q

What can be seen on histology of Avipoxvirus?

A

Bollinger bodies: eosinophilic granular intracytoplasmic inclusion bodies

-Borrel bodies inside of Bollinger bodies

45
Q

How is Ulcerative dermatosis transmitted?

A

Through damaged skin or by coitus of sheep

46
Q

Ulcerative dermatosis manifests in 2 clinical forms:

A

-Lip and leg ulceration

-Venereal form

Sem 3: Viro (17 decks)

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