Heredity Flashcards

1
Q

What did the bible propose about fetal development and inheritance?

A

The experience’s of the mother during pregnancy could directly affect fetal development (ex: Elephant man).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What were the “gemmules” that Darwin proposed? How did they contribute to inheritance?

A

Molecules which were emitted by parts of the body and aggregated in the gonads, affecting offspring development.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which of the ancients proposed an method of inheritance similar to Darwin’s pangenesis?

A

Hippocrates (or the Hippocratics).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What were Aristotle’s views on inheritance?

A

Form + Potential = Actuality.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What did Thinkers at Darwin’s time understand about hybridization?

A

That hybridizations between different animals could yield offspring species which were intermediate in appearance.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What model of inheritance, proposed by Lamarck, was still widely accepted in Darwin’s time?

A

The inheritance of acquired characteristics.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is meant by “Genetic Purity”? What are the societal implications of this?

A

One group has “stuff” that other groups don’t have. Mixing leads to “pollution” Had racial implications when it was first proposed, now only considered for animal breeding.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What term best describes the transmission of pre-existing form?

A

Preformationism.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Describe “blending inheritance”. What kind of modern inheritance do we know which validates these views?

A

Offspring will be an intermediate phenotype between the parents. Species which have co-dominant alleles (ex: snapdragons) can exhibit this.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How did Mendel’s early life differ from that of Darwin?

A

Mendel’s family was very poor. He only attended university for 2 years and then ran out of money. Darwin was filthy rich.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What did Mendel do when forced to leave university due to financial troubles? Was this common for people in his situation?

A

Became a monk of the Augustinian Order at Brno. Many monks also desired a stable life and a place to pursue their intellectual interests.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What was Mendel’s part time job while living as a monk? What did he aspire to become? Why was he not successful?

A

He was a part time teacher but wanted to become a full teacher. Failed his oral exams twice because he was a pathologically nervous test-taker.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What was Mendel naturally good at? How did he want to apply this to science?

A

Naturally good with numbers, wanted to pursue science in a quantitative manner.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What was Gregor Mendel’s most notable achievement? Why did he not continue his work?

A

His pea hybridization experiments. He quit science because he couldn’t repeat his findings in another plant (which turned out to be super edge-case and weird).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Why are Mendel’s scientific ideas so difficult to reconstruct, compared with Darwin’s?

A

All of Mendel’s notes were burned after his death, so there’s not a lot to go on.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What 3 modern concepts did Mendel observe in his pea plant experiments?

A
  1. Segregation of traits
  2. Particulate inheritance
  3. Independent assortment
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Why were Mendel’s observations of the segregation of traits different than experiments which had been done before?

A

He used quantitative measures to try to derive an abstract model of inheritance.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

How did Mendel avoid self-pollination during his experiments?

A

Cut the stamens off the pea flowers.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Were Mendel’s observations only relevant to flower colour?

A

No, he observed these same ratios for many different plant traits.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is meant by “segregation of traits”?

A

Uniform parents can give differing progeny.

21
Q

What is meant by “particulate inheritance”?

A

Hereditary factors behave as distinct entities that cannot be divided, rather than as a continuous spectrum or a fluid.

22
Q

What is meant by “independent assortment”?

A

Different genes independently separate from one another when reproductive cells develop.

23
Q

What eminent botanist did Mendel get interested in his work? What did this man suggest?

A

Karl Nageli became interested, and suggested that Mendel repeat his experiments using hawkweed (a terrible idea, hawkweed is some weird shit).

24
Q

What characteristic did Mendel’s genetic approach rely on?

A

Nuclear sexual genetics.

25
Q

How did Darwin’s “gemmules” differ from Mendel’s particulate model?

A

Darwin proposed that these molecules changed over the course of an individual’s life.

26
Q

What is August Weismann known for having proposed regarding the distinction between cell types?

A

The difference between germplasm (sex cell precursor) and somatoplasm (rest of cells).

27
Q

Where did August Weismann think that the particles of inheritance were located in the body? How was he wrong about these particles?

A

On the chromosomes. But he thought that they had a ton of complete sets of hereditary particles passed on from previous generations (not a thing).

28
Q

What approach to studying inheritance did Sir Francis Galton pioneer? Describe it.

A

The biometrical approach, which applies statistics to biological problems.

29
Q

How did Galton’s approach to studying heredity vary from Mendel’s?

A

Mendel studied discrete (discontinuous) variation, while Galton studied quantitative (continuous) variation. Mendel also proposed atoms of inheritance while Galton didn’t account for these.

30
Q

What principle of heredity did Galton and Mendel both agree on?

A

1/2 of your hereditary material comes from each parent, therefore 1/4 comes from each grandparent.

31
Q

What science (modern psudoscience) is Galton considered to be the founder of?

A

Eugenics. How to breed people to make better people (super morally questionable).

32
Q

How was Mendel’s work viewed in the late 19th century?

A

Its importance was not recognized. Mendel was viewed simply as a pea breeder.

33
Q

Who were the 3 “rediscoverers” of Mendel’s work? Who was the “apostle”?

A
  1. Hugo de Vries
  2. Carl Correns
  3. Erik von Tschermak
    Apostle: William Bateson
34
Q

What 5 observations did Hugo de Vries derive which had already been discovered by Mendel?

A
  1. Traits derived from separate hereditary units
  2. Dominance and recessiveness
  3. Reappearance of recessive trait in F2 generation
  4. 3:1 ratio in F2 generation
  5. Some F2s bred true, while others segregated
35
Q

What did Hugo de Vries call the hereditary units he “discovered”?

A

“Intracellular pangenes”.

36
Q

What did Hugo de Vries not mention in his paper on heredity?

A

He didn’t credit ya boi Mendel, and a bunch of people shit on him for it.

37
Q

What did Carl Correns study? What was his relationship with Hugo de Vries? What became of this?

A

Paired traits in peas and in maize (basically same as Mendel). He disliked de Vries, and so shit on him for not crediting Mendel’s work.

38
Q

What did Erik von Tschermak study?

A

The heredity of traits in pea plants (same as Mendel). He observed all the same results as Mendel.

39
Q

Who was William Bateson?

A

A lifelong defender of Mendel’s work in heredity.

40
Q

Who came up with the term “genetics”? What about “gene”?

A

Genetics: William Bateson
Gene: Wilhelm Johannsen

41
Q

Who differentiated the terms “phenotype” and “genotype”?

A

Wilhelm Johannsen, a Danish Botanist.

42
Q

What were the 4 main reasons for Thomas Hunt Morgan’s objection of Mendelism?

A
  1. Mendel’s laws don’t hold in animals
  2. Dominance/recessiveness can’t explain the 1:1 sex ratio
  3. Progeny are often intermediate in appearance
  4. No physical molecules of inheritance identified
43
Q

What disproved idea regarding inheritance did skeptics associate with Mendel’s work?

A

Preformationism.

44
Q

What did “Mendel’s Principles of Heredity: a defense”, written by William Bateson, argue?

A

That both discrete and continuous characters can be understood in terms of Mendelian genetics.

45
Q

What did Walter Sutton observe which strengthened Mendel’s model of inheritance?

A

He saw that chromosomes in meiosis behave the same way that Mendel’s hereditary determinants do.

46
Q

What did William Bateson discover in regards to genetic inheritance?

A

That genes in plants undergo co-segregation and can wind up in the same sex cells.

47
Q

What did Thomas Hunt Morgan’s lab use as a model organism? Why? Who worked in this lab?

A

Used fruit flies as a model organism because of short generation times. Herman Muller, Alfred Sturtevant, and Calvin Bridges all worked here.

48
Q

What were the Thomas Hunt Morgan lab’s 5 notable achievements?

A
  1. Sex linkage
  2. Genetic maps
  3. One-dimensional genetic information
  4. Creation of mutants for gene discovery
  5. Related chromosomal aberrations to mutant phenotypes
49
Q

What evolutionary idea did Thomas Hunt Morgan’s lab anticipate?

A

Population genetics (as a way to relate Mendelian genetics to evolutionary theory).