Hereditary non-polyposis colorectal cancer

Question 1

HNPCC, other name

Answer 1

Lynch syndrome

Question 2

Lynch syndrome, cause

Answer 2

Inherited mutations in mismatch repair genes involved in control of DNA replication

Question 3

Proportion of Lynch syndrome from total colorectal cancer

Answer 3

2-4 %
Most common syndrome form of colonic cancer

Question 4

Lynch syndrome, common location

Answer 4

Right colon

Question 5

Lynch syndrome, genes involved (most common)

Answer 5

5 identified
MSH2
MLH1

Question 6

Lynch syndrome, pathogenesis

Answer 6

Patients accumulate 100 times more mutations than normal if the normal gene is silenced

Question 7

In Lynch syndrome, where is the location of more mutation, how many exist in humans and hence how is it called

Answer 7

Microsatellites
50 000 - 100 000 in humans
Microsatellite instability (MSI)