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Pstología > Breast cancer > Flashcards

Breast cancer Flashcards

1
Q

Genes implicados en cancer de mama, en orden de riesgo (7)

A

BRCA1
BRCA2
TP53
PTEN
STK11
CDH1
PALPB2
ATM (moderate penetrance)
CHEK 2 (moderate penetrance)

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2
Q

Comentarios BRCA1

A

Mayormente TNBC

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3
Q

Comentarios BRCA2

A

MAyormente ER +

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4
Q

Comentarios TP53

A

Mayormente ER + y HER2 +

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5
Q

Comentarios PTEN

A

Asociado con t. benignos

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6
Q

Función gen ATM

A

Detecta daño DNA y activa p53

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7
Q

Funcion de los gnees BRCA 1-2 y CHEK2

A

Reparación del DNA

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8
Q

Como el estrógeno aumenta el reisgo de cancer de mama

A

Aumenta la producción local de factores de crecimiento
Regula la expresión de deocenas de genas que pueden contribuir directamente en el crecimiento y desarrollo tummoral

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9
Q
A
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Pstología (16 decks)

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