HepB Serology

Question 1

What is the HepB status?
+ve HBsAg
-ve HBsAb
+ve HBeAg
-ve HBeAb
+ve HBcAb IgM
-ve HBcAg IgG
+ve HBV DNA

Answer 1

Acute infection

HBcAb IgM= recent infection <6 months

HBcAb IgM replaced to HBcAb IgG = resolved or chronic infection

Question 2

What is the HepB status?
+ve HBsAg
-ve HBsAb
+ve HBeAg
-ve HBeAb
-ve HBcAb IgM
+ve HBcAg IgG
+ve high HBV DNA

Answer 2

Chronic active infection

HbeAg is found in acute/ chronic and indicates active viral replication

HBeAg can be used to distinguish between active chronic/ inactive chronic infecton

Question 3

What is the HepB status?
+ve HBsAg
-ve HBsAb
-ve HBeAg
+ve HBeAb
-ve HBcAb IgM
+ve HBcAg IgG
+ve low HBV DNA

Answer 3

Past and/or chronic infection and inactive carrier (non-infective)

HBeAg used to determine active/inactive chronic infection

+ve HBV DNA= low viral load

HBcAg IgG lingers after initial infection and indicates past resolved infection. Also helps against future infections

Question 4

What is the HepB status?
-ve HBsAg
+ve HBsAb
-ve HBeAg
+ve HBeAb
-ve HBcAb IgM
+ve HBcAg IgG
-ve HBV DNA

Answer 4

Immune from past infection

No HBsAg but yes to HBsAb
+ve HBcAg IgG= lingers from initial infection

Core antibodies used to distinguish between recent, past, and present infections

Question 5

How are transaminases affected in HepB infection?

Answer 5

Acute HepB= elevated
Chronic active HepB= elevated
Chronic carrier HepB- normal
Immune from infection- normal/ elevated
Immune from vaccine- normal

Question 6

What is the HepB status?
-ve HBsAg
+ve HBsAb
-ve HBeAg
-ve HBeAb
-ve HBcAb IgM
-ve HBcAg IgG
-ve HBV DNA

Answer 6

Immune following vaccination OR cleared past infection.

Needs more serology testing to distinguish between the two.