Hepatitis serology Flashcards
Understand what the following serological tests mean:
HBsAg
Anti- HBs:
Anti- HBc:
IgM anti HBc
HBsAg:
• Active infection whether acute or chronic
Anti- HBs:
• Immunity (whether through vaccine or infection)
Anti- HBc:
• Infection whether past or current
IgM anti HBc:
• Indicates recent infection to Hep B
Interpret the following test result:
HBsAg: Negative
Anti- HBc: Negative
Anti- HBs: Negative
- No infection
* At risk of infection
Interpret the following test result:
HBsAg: Negative
Anti- HBc: Positive
Anti- HBs: Positive
• Immune due to resolved infection
Interpret the following test result:
HBsAg: Negative
Anti- HBc: Negative
Anti- HBs: Positive
• Immune due to Hep B vaccination
Interpret the following test result: HBsAg: Positive Anti- HBc: Positive IgM anti HBc: Positive Anti- HBs: Negative
• Acute HBV infection
Interpret the following test result:
HBsAg: Positive
Anti- HBc: Positive
Anti- HBs: Negative
• Chronic HBV infection
Understand the components of the liver function test and what their amount may indicate:
• Bilirubin
• Albumin
Bilirubin
• Haem metabolite, conjugated in liver
• High = liver issues (jaundice)
Albumin
• Measures the main proteinmade by the liver
• Low levels = injury
Understand the components of the liver function test:
• Total protein
Measures albumin and all other proteins in blood, including antibodiesmade to help fight off infections
What does high levels of gamma glutamyl transferase indicate in a liver function test?
• Liver disease/ damage
What is alkaline phosphatase and what does high levels of alkaline phosphatase indicate in a liver function test?
What it is:
• An enzyme related to thebile ducts
High levels:
• Bile duct is blocked
What is aspartate transaminase and what does high levels indicate?
What it is:
• Enzyme release by liver due to injury
High levels:
• Liver injury
What does elevated levels of alanine transaminase indicate?
Liver damage
