Hepatitis E Flashcards
What is the viral family of hepatitis E?
Hepeviridae
Describe the molecular characteristics of hepatitis E
Non-enveloped +ive sense ssRNA
Where is hepatitis E endemic?
SE Asia
Some parts of Africa
What is the incubation period for hepatitis E?
~40 days
In what population is hepatitis E infection particularly dangerous?
Pregnant women (case-fatality rate 15-25%)
What are the symptoms of hepatitis E infection?
As for hepatitis A
Cholestasis also a common feature
Describe the pathogenesis of hepatitis E
Entry across intestinal mucosa
Affects Kupfer cells and hepatocytes
Secreted in faeces
Is long term immunity acquired to hepatitis E?
Yes (IgG persists)
How is hepatitis E diagnosed?
Serology (IgM and raising IgG)
Nucleic acid assays
How can hepatitis E be prevented?
Sanitation
Can IVIG be given for hepatitis E prevention?
No (ineffective, cf HAV)
How is hepatitis E treated?
Supportive therapy only
