Constipation Flashcards
1
Q
What are the 5 classes of laxatives?
A
Bulking agents Faecal softeners and lubricants Osmotic laxatives (saline, disaccharide, polyols, macrogols) Stimulant laxatives Other
2
Q
Bulking agents
A
Bran
Psyllium
3
Q
How do bulking agents work?
A
Greater faecal water retention
increased normal reflex bowel activity
4
Q
How do faecal softeners and lubricants work?
A
Detergents (enhance mixture of water into faeces)
OR lubricant mineral oil (e.g. liquid paraffin)
5
Q
Docusate
A
Faecal softener and lubricants
6
Q
Magnesium sulphate (Epsom salts)
A
Saline laxative
7
Q
Lactulose
A
Disaccharide
8
Q
Sorbitol
A
Polyol
9
Q
Bisacodyl
A
Stimulant laxative
10
Q
Senna
A
Stimulant laxative
11
Q
Metoclopromide
A
Anti-emetic drug (D2-receptor antagonist)
Also 5HT4-receptor agonist which together with inhibition of D2 increases motility of GIT by increasing ACh release