Constipation Flashcards

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1
Q

What are the 5 classes of laxatives?

A
Bulking agents
Faecal softeners and lubricants
Osmotic laxatives (saline, disaccharide, polyols, macrogols)
Stimulant laxatives
Other
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2
Q

Bulking agents

A

Bran

Psyllium

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3
Q

How do bulking agents work?

A

Greater faecal water retention

increased normal reflex bowel activity

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4
Q

How do faecal softeners and lubricants work?

A

Detergents (enhance mixture of water into faeces)

OR lubricant mineral oil (e.g. liquid paraffin)

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5
Q

Docusate

A

Faecal softener and lubricants

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6
Q

Magnesium sulphate (Epsom salts)

A

Saline laxative

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7
Q

Lactulose

A

Disaccharide

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8
Q

Sorbitol

A

Polyol

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9
Q

Bisacodyl

A

Stimulant laxative

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10
Q

Senna

A

Stimulant laxative

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11
Q

Metoclopromide

A

Anti-emetic drug (D2-receptor antagonist)

Also 5HT4-receptor agonist which together with inhibition of D2 increases motility of GIT by increasing ACh release

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