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Infection And Clinical Practice > Hepatitis > Flashcards

Hepatitis Flashcards

1
Q

Specific examples of hep A transmission?

A

Contaminated food and water - shellfish

Poor sanitation

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2
Q

What are the prodromal symptoms of hep A and E?

A

Nausea, anorexia, headaches, arthralgias
Vomiting and or diarrhoea
Fever possibly

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3
Q

What happens to smokers during Hep A prodromal period?

A

Lose taste for tobacco

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4
Q

What does the prodromal phase of hep A progress onto?

A

Icteric phase - jaundice (obstructive type), hepatosplenomegaly lymphadenopathy, pruritis, RUQ pain
Can get vasculitis type rash on lower limbs

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5
Q

Investigations for Hep A?

A

Anti HAV IgM, IgG

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6
Q

How long can recovery take for hep A?

A

Up to 6m

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7
Q

What type of virus is HBV?

A

DNA virus

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8
Q

How is hep A transmitted?

A

Fecal oral

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9
Q

Blood transfusions before what year are significant?

A

1991

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10
Q

What 3 features, if present, are more prominent in HBV than HAV?

A

Jaundice
Rash
Arthralgias

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11
Q

What test results indicate acute HBV infection?

A

HBsAg
HBeAg
Anti-HBc IgM
Anti-HBc IgG

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12
Q

What test results indicate a recovered HBV infection?

A

Anti-HBs

Anti-HBc IgG

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13
Q

What test results indicate someone who is vaccinated against HBV?

A

Anti-HBs

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14
Q

What is given for the HBV vaccine?

A

Anti-HBs

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15
Q

What differentiates someone who is immune from HBV due to cleared infection to someone immune due to vaccination?

A

Both have +ve anti-HBs

Someone who has had the infection will also have anti-HBc IgG

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16
Q

What results would indicate someone with chronic HBV infection?

A

HBsAg

Anti-HBc IgG

17
Q

What marker can be used in acute HBV infection to assess severity and treatment response?

A

HBV-DNA (PCR)

18
Q

What HBV test is used for screening?

A

HBsAg

19
Q

2 methods of detection of HCV infection? Which is acute and which is chronic?

A

HCV-RNA detectable via PCR during acute phase

Anti-HCV Abs detectable during chronic phase

20
Q

What proportion of people with acute HCV infection go on to develop chronic infection?

A

2/3

21
Q

Rx for chronic HCV?

A

PEG interferon alpha
Ribavirin
+/- triple therapy

22
Q

Which hepatitis infections is it possible to vaccinate against?

A

HAV

HBV (and indirectly HDV)

23
Q

What are the 2 types of infection with HBV + HDV?

A

Co-infection (more severe HBV infection)

Superinfection (reactivation of chronic HBV)

24
Q

What risks does HDV infection add to HBV infection?

A

Increased risk fulminant hepatitis and liver failure

25
Q

How is Hep E spread? (With specific examples)

A

Fecal oral
Pork, deer
Bodily fluids

26
Q

Generally what methods are used in detection of non-HBV viral hepatitis?

A

RNA serology (PCR)

27
Q

In what group of people does HEV infection present a 25% mortality rate?

A

Pregnant women

Infection And Clinical Practice (13 decks)

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