Hepatitis Flashcards
genus of picornaviridae
hepatovirus
cause of hepa A
picornavirus
itsura ng picornavirus
spherical particle w/ ssRNA
does hepa A cause chronic live disease
no
hepa A has ____ serotypes ______ genotypes
1;7
how to destroy picornavirus
autoclave boiling dry heat UV formalin chlorine
percent of hepa A among all hepa
40%
percentage of complete recovery
99%
serological findings in lab diagnosis for hepa A
HAV
anti HAV
IgM anti HAV
what serological finding in hepa A indicates recent infection
IgM antiHAV
cause of hepa B
hepadnavirus
MOT of hepa A
fecal oral route
MOT of hepa B
parenterally
____ of hepa B develops chronic liver dis
5-10%
morphologic forms of hepa B
small spherical
tubular or filamentous
large spherical (Dane particle)
composition of Dane particle Hepa B
HBsAg envelop
HBcAg core
phenotypes of HBsAg
ayw
adw
ayr
adr
major risk factor for hepa B
sexual promiscuity
drug abuse
1st sign of recovery from hepa B
renewed appetite
clinical syndromes of Hepa B
acute
chronic
primary Hepatocellular carcinoma
pathology of hepa B
spotty parenchymal cell degen
diffuse lobular inflammation
disruption of liver cell cords
screening for hepaB
agglutination test
confirmatory for hepa B
ELISA
PCR
sero of hepa B
HBV HBsAg HBeAg HBcAg anti HBs anti HBe anti HBc
hepa b sero that indicates viral replication
HBeAg
hepa B sero that indicates past infection
anti HBsAg
anti HBcAg
trisls for hepa B tx
interferon
adenine arabinoside
steroids
azathioprine
hepaB immune globulin is given to
post exposure prophylaxis of + mother
mucosal xposure
cause of hepaC
hepacivirus
hepacivirus is under
flaviviridae
major cause of post transfusion hepa
hepa C
_____ of HCV patients develop chronic illnesses
70-90%
MOT of hepaC
parenteral
sexual
____ is not protective
anti HCV
form of hepa C that often leads to cirrhosis
chronic form
markers of HepaC
HCV
antiHCV
smallest known human pathogen
hepa D
itsura ng hepa D
HDAg surrounded by HbsAg envelop
hepa D infects only those with
underlying HBV inf
markers of hepa D
HDV
anti HDV
HDAg
_____ is protective against delta infection
hepa B vaccine
Mot of hepa F
fecal oral
water borne
where was hepa F found
one experimental monkey
genome of hepa F
dsDNA
only double stranded na ekek
reovirus
not know ro cause human disease
reovirus
causes inapparent infections
reovirus
most important cause of infantile diarrhea
rotavirus
single +, naked segmented
rotavirus
MOT of rotavirus
fecal oral route
incubation period of rotavirus
1-3days
most frequent pathogen under rotavirus
group A
viral excretion of rotavirus in stool persists until
50 days
rotavirus affects the
vili of small int
rotavirus diarrhea is caused by
impaired sodium and glucose absorption
host response to rotavirus
IgM > IgG and secretory IgA
lab diagnosis for rotavirus
ELISA
IEM
LPA
PCR
single +, naked icosahedral
calicivirus
star of David appearance
calicivirus
why star of David
bcoz of 5peplomers
incubation for calici
24-48hrs
causes usually nonbloody non,ucoid stool
norwalk virus
first incidence of norwalk vrus
norwalk, ohio
lab diagnosis for norwalk virus
RT-PCR
ELISA
IEM
is there vaccine for norwalk virus
none
how dies pironaviridae emter
oropharynx
intestinal mucosa
upper RT
______ are limited to RT
rhinovirus
infections by picornaviridae are usually
asymptomatic
prototype of picornaviridae
poliovirus
receptor recognized by poliovirus are found in
anterior horn cells of spinal cord dorsal motor ganglia motor neurons skel muscle lymphoid cells
MOT of picornaviridae
fecal oral
outcomes from poliovirus
asymptomatic illness
abortive poliomyelitis
nonparalytic
paralytic
types of paralytic poliomyelitis
paralytic poliomyelitis
bulbar poliomye
postpolio syndrome
viruses associated with herpangina
coxsackie A
viruses assoc with pleurodynia and myocarditis
coxsackie B
vesicular lesions arecalled
herpangina
hand foot mouth disease caused by
cox A16
other term for pleurodynia
bornholm disease
devil’s grip
acute febrile illness accompanied by headache and signs kf meningeal irritation
viral (aseptic) meningitis
feevr and rash may occur in px with
echo
cox
CSF results from polio or enetero shows
lymphocytic pleocytosis
CSF glucose is normal or slightly low in
viral meningitis
where is piliovirus isolated
phrynx
where does poliovirus grow well
monkey kidney tissue culture
serological finding in poliovirus inf
IgM
4-fold increase in Ab titer
types of polio vaccine
OPV
IPV
which vaccine is made from live attenuated poliovirus
OPV
which vaccine is cheaper and commonly used
OPV