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Chapter 35 - Hepatitis Viruses (RVSP) Flashcards

0
Q

Classic signs of hepatitis virus infection

A

Jaundice and elevated liver enzymes

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1
Q

Main target of hepatitis viruses

A

Liver

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2
Q

Causes Hepa A

A

Picornavirus

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3
Q

Genus of Picornavirus

A

Hepatovirus

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4
Q

5 RNA hepatitis viruses

A
  • Hepatitis A
  • Hepatitis C
  • Hepatitis D
  • Hepatitis E
  • Hepatitis G
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5
Q

DNA hepatitis virus

A

Hepatitis B

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6
Q

Naked hepatitis viruses

A
  • Hepa A

- Hepa E

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7
Q

MOT of Hepa A

A

Fecal-oral route

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8
Q

Incubation period of Hepa A

A

About 1 month

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9
Q

Hepa viruses that only cause acute liver disease

A

Hepa A

Hepa E

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10
Q

Responsible for 40% of all hepatitis cases

A

Hepa A

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11
Q

Hepa A agent

A

HAV

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12
Q

Hepa A; detectable at onset of symptoms; persists throughout life

A

Anti-HAV

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13
Q

Hepa A; indicates recent infection; (+) 4-6 mts after infection

A

IgM anti-HAV

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14
Q

Causes Hepa B

A

Hepadnavirus

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15
Q

MOT of Hepa B

A

Parenteral

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16
Q

Incubation period of Hepa B

A

3 mts

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17
Q

3 morpholigic forms of Hepa B

A
  • small spherical particles
  • tubular/filamentous
  • large spherical virions (Dane particles)
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18
Q

4 phenotypes of HBsAg

A
  • adw
  • ayw
  • adr
  • ayr
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19
Q

HBsAg positive for 2 occasions at least 6 mts apart

A

Chronic carrier

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20
Q

3 clinical syndromes of Hepa B

A

Acute infection
Chronic infection
Primary hepatocellular carcinoma (PHC)

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21
Q

Hepa B syndrome; long incubation period, insidious onset

A

Hepa B acute infection

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22
Q

First sign of recovery for Hepa B acute infection

A

Renewed appetite

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23
Q

Hepa B syndrome; usually occurs after mild or inapparent illness

A

Hepa B chronic infection

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24
Q

Detected in Hepa B chronic infection

A

Elevated liver enzymes

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25
Q

Latent period between HBV infection and PHC

A

9-35 years

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26
Q

Screening test for Hepa B

A

Agglutination test

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27
Q

Confirmatory tests for Hepa B

A

ELISA

PCR

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28
Q

Detects Hepa B Ag and Ab

A

ELISA

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29
Q

Detects Hepa B viral DNA

30
Q

Pathology of PHC

A
  • spotty parenchymal cell degeneration
  • diffuse lobular inflammatory reaction
  • disruption of liver cell cords
31
Q

Hepa B agent

32
Q

Hepa B surface Ag

33
Q

Hepa B; indicates viral replication

34
Q

Hepa B core Ag

35
Q

Hepa B; indicates past infection; immune

36
Q

Hepa B; suggests presence of HBV

37
Q

Hepa B; indicates past infection

38
Q

Hepa B; indicates high infectivity

39
Q

Hepa B; indicates low infectivity

A

Anti-HBeAg

40
Q

Hepa B; indicates new infection; acute

A

IgM anti-HBcAg

41
Q

Hepa B; indicates old infection; chronic/resolving

A

IgG anti-HBcAg

42
Q

Time when HBsAg is detectable

43
Q

Time when HBeAg is detectable

44
Q

Time when Anti-HBc is detectable

45
Q

Time when anti-HBe is detectable

46
Q

Time when anti-HBs is detectable

47
Q

Used for post-exposure or newborns of HBsAg (+) mothers and for mucosal exposure to secretions of individuals who are HBsAg (+)

A

Hepa B immune-globulin

48
Q

Family of Hepa C causative agent

A

Flaviviridae

49
Q

Genus of Hepa C causative agent

A

Hepacivirus

50
Q

Accounts for 90% of non-A, non-B hepatitis infections

51
Q

Major cause of post-transfusion hepatitis

52
Q

MOT of Hepa C

A

Parenteral

53
Q

2 clinical syndromes of Hepa C

A
  • acute form

- chronic form

54
Q

Mtd for Hepa C Ab detection

55
Q

Mtd for HCV-RNA

56
Q

Hepa C agent

57
Q

Hepa C antibody

58
Q

Hepa C syndrome; similar to acute Hepa A and B but inflammatory response is less and symptoms are milder

A

Acute form

59
Q

Hepa C syndrome; more prevalent than HBV, often leads to cirrhosis

A

Chronic form

60
Q

Composition of the Delta agent/Hepa D

A

HDAg surrounded by HBsAg envelope

61
Q

Smallest Hepa virus

62
Q

Hepa D; patients that are more likely to develop fulminant hepatitis

A

Delta agent carriers

63
Q

Mtds for Hepa D Ag/Ab detection

64
Q

Mtd for Hepa D; to detect HDV-RNA

65
Q

Hepa D agent

66
Q

Delta Ag; detectable in early acute infection

67
Q

Hepa D; indicates past or present infection

68
Q

Patients where Hepa E is more serious

A

Pregnant women

69
Q

Mutant strain of HBV

A

Hepatitis F virus

70
Q

Genome of Hepa F virus

71
Q

Genome of Hepa G virus

72
Q

Family of Hepa G virus

A

Flaviviridae

MycoViro (9 decks)

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