Hepatic Neoplasms Flashcards
What is the benign neoplasm in the liver?
Hepatocellular Adenoma
What are the Malignant tumors of the Liver?
• Hepatoblastoma
• Hepatocellular Carcinoma
• Cholangiocarcinoma
• Other
• Metastasis
What are the 2 types of Nodular Hyperplasia that we see in the liver?
- Focal Nodular Hyperplasia
- Nodular Regnerative Hyperplasia
Focal Nodular Hyperplasia
• Who is it typically seen in?
• What is the morphology?
• Etiology?
- Tyically young or middle aged
- Spontaneous mass lesion in an otherwise nl liver that is well demarcated but not well encapsulated and can be pretty large
- Often associated with Oral Contraceptive Use
Nodular Regenerative Hyperplasia
• What does this appear similarly to grossly?
• How does it differ from focal Nodular Hyperplasia?
• What condition can it cause?
• Associations to make with this appearance?
Appears similar to Cirrhosis but does NOT have fibrosis on microscopy. Similar to cirrhosis it can cause portal Hypertension.
• Usually this is an incidental finding and occurs in association with conditions affecting intrahepatic blood flow, including solid-organ (particularly renal) transplantation, hematopoetic stem cell transplantation, and vasculitis
What factor is common to both Focal Nodular and Nodular Regerative Hyperplasias?
Alteration of Portal Blood Supply
, arising from obliteration of portal vein radicles and compensatory augmentation of arterial blood supply.
What disease is shown here?
• Key features
Nodular Regenerative Hyperplasia
• Grossly liver becomes nodular and resembles fibrosis but when cut there is no fibrosis and therefore a lack of fibrous septa giving it a more “nice roast-like” appearance
What disease is shown here?
• key features?
Focal Nodular Hyperplasia
• Characterized by abnormal architecture, bile ductular proliferation, and malformed vessels
What type of nodular hyperplasia is likely represented by this gross liver specimen?
• Key features?
Focal Nodular Hyperplasia
Depressed, white scar with septa radiating to the periphery
What Disease is shown here?
• Key features?
Focal Nodular Hyperplasia
• Hepatocyte Regernation and Chronic Inflammation
• Broad Fibrous Scar with Hepatic Arterial and Bile Duct Elements
What are the Key Features in this tissue?
• Disease?
Reticulin Stain shows widened plates of hepatocytes in the abscence of fibrosis, this is indicative of Nodular Regenerative Hyperplasia
What type of hyperplasia is shown in this liver biopsy?
• Key features?
Sinusoids are dilated in the absence of inflammatory infiltrates or necrosis, this is indicative of **Nodular Regenerative Hyperplasia
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Remember this disease is associated with association with conditions affecting intrahepatic blood flow, including solid-organ (particularly renal) transplantation, hematopoetic stem cell transplantation, and vasculitis
What feature of regenerative Nodular Hyperplasia is shown here?
Atrophic Hepatic Cords on the left and Thick plump cords on the right
Disease?
• Characteristics?
What is the THE MOST COMMON BENIGN liver tumor?
• what key feature are you looking for in these?
Cavernous Hemangioma
• key features: Blood Filled Vascular Channels surrounded by a Dense Fibrous Stroma