HEPADNAVIRIDAE Flashcards
an outer protein expressed in excess when the virus replicates in the liver
hepatitis B surface antigen
an inner protein, which is expressed only within hepatocytes in the liver.
hepatitis B core antigen
shed in the blood when the virus replicates, and its presence is associated with high infectivity.
hepatitis B e antigen
Surface antigen originally termed
Australia antigen
Virion
Dane particle
Envelope protein Three Polypeptides
p23, p26, p31
primary route of transmission.
Percutaneous exposure to blood or blood products
most common routes of transmission
heterosexual and male homosexual
High-risk groups
IV drug abusers, MSM,individuals from endemic areas, persons with household or sexual contacts with HBV carriers,health care personnel, people with tattoos or bodypiercings, and infants born to HBV-positive mothers.
Incubation period
60-150 days
Average incubation
90 days
presence of HBs Ag in the blood
Infectious period
marker of high infectivity
Hepatitis B e antigen
Acute infection is accompanied with
rise in ALT of >500 IU/L and jaundice.
The incubation period for an acute HBV infection usually is
1 to 3 months
most reliable marker for identifying HBV infection.
Hepatitis B surface antigen (HBsAg)
The presence of HBsAg 6 months after acute infection indicates that the patient
chronic carrier
appears early in the course of disease, during the acute infection.
IgM (anti-HBcAg)
indicates the patient is in convalescence
Anti-HBsAg
The presence of HBeAg (hepatitis B e antigen) indicates
high infectivity
The best indication of active viral replication and a high state of infectivity is the presence of
HBV DNA in the serum
HBsAg Positive, HBeAg Positive, Anti-HBc IgM Positive. Interpret:
Acute Hepatitis B (High Infectivity)
HBsAg Negative, Anti-HBs Positive, Anti-HBc Negative. Interpret:
Vaccinated Individual
HBsAg Negative, Anti-HBs Positive, Anti-HBc Positive. Interpret:
Recovered from Past Hepatitis B Infection
