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MYCOLOGY AND VIROLOGY > DNA VIRUSES PART 2: POXVIRUS > Flashcards

DNA VIRUSES PART 2: POXVIRUS Flashcards

1
Q

Subtype of Small pox which caused the most severe disease with case fatality of 30% and occurred mainly in Asia

A

Variola Major

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2
Q

Pox virus infection that is systemic infection that spreads the virus throughout the body

A

Fulminant

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3
Q

Transmission of smallpox

A

Respiratory droplets

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4
Q

Transmission of molluscum, orf, monkeypox

A

Direct contact

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5
Q

Zoonoses viruses of poxviridae

A

Orf and monkeypox

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6
Q

Intact form of the virion of poxvirus from a vesical fluid specimen

A

Mulberry form

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7
Q

Damaged form of the virion of poxvirus from a scalp specimen

A

Capsule form

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8
Q

Give the code of the anti viral tx: Brimcidofovir/Tembexa

A

CMX001

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9
Q

Give the code of the antiviral tx: Tecovirimat/Tpoxx

A

ST246

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10
Q

Incubation period of variola virus

A

10-17 days

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11
Q

Lesions are present in greater concentration on the head and limbs including the palms and soles

A

Centrifugal distribution

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12
Q

Rash: small, round changes in skin color

A

Macules

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13
Q

Rash: slightly elevated with no fluid

A

Papules

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14
Q

Rash: containing a bubble of fluid

A

Vesicles

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15
Q

Rash: containing a purulent material consisting of necrotic inflammatory cells

A

Pustules

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16
Q

Vaccines for Variola virus

A

ACAM2000, ARSV (Aventis Pasteur Smallpox Vaccine)

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17
Q

Patients with Variola virus are infectious after the _ has appeared

A

Rash

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18
Q

Rash appears in

A

24-48hrs (1-2days)

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19
Q

A Jennerian vaccine named for Edward Jenner in 1796(1798)

A

Vaccinia

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20
Q

Considered a bioterrorism agent

21
Q

Smallpox is caused by Variola virus characterized by

A

Vesicular and pustular eruption

22
Q

Causative agent: Variola Virus
* Centrifugal distribution
* Most dense on face and
extremities
* Lesions appear during a 1– 2 day
period
* Lesions evolve at the same rate

A

Classic Smallpox Rash

23
Q

Distribution of chickenpox

A

Centripetal

24
Q

subtype of ordinary type smallpox rash
* have distinct areas of normal skin between discrete pustules

A

Discrete subtype

25
Q

subtype of ordinary smallpox rash
* have a confluent rash on the face but with discrete lesions elsewhere

A

Semi-confluent subtype

26
Q

Subtype rash of ordinary type smallpox
- confluent rash on the face and the extremities

A

Confluent subtype

27
Q

3 Major Classifications of
Smallpox:
*More rapidly progressive, malignant disease develops, which is almost always fatal within 5 to 7 days.
* Characterized by a severely prostrating prodromal illness with high fever, head ache, back pain, and abdominal pain.
* difficult to diagnose, and they are exceedingly

A

Hemorrhagic

28
Q

3 Major Classifications of
Smallpox:
characterized by a more abrupt onset of illness and prostration than classical smallpox.
* confluent lesions develop slowly, never progressing to the pustular stage, remaining soft, flattened, and velvety to
the touch.
* Invariably fatal
* However, if an individual survives flat smallpox, they rarely experience typical scarring afterward

A

Malignant (Flat)

29
Q

Causative agent of Alastrim

A

Variola minor

30
Q

Complication: Chronic Viral Conjunctivitis

A

Vaccinia Virus

31
Q

derivative of vaccinia virus that has persisted in in India in water buffalo

A

Buffalopox virus

32
Q

Host reservoir of Monkeypox

A

Gambian rats

33
Q

caused by an orthopox virus

34
Q

Monkeypox commonly occurs in

A

West and central Africa

35
Q

Clades of monkeypox that has the highest fatality rate

A

Congo Basin Clade

36
Q

Characteristic feature of Monkeypox

A

Inguinal lymphadenopathy

37
Q

Incubation period of monkeypox

A

7–17 days

38
Q

The vesicular rash appears about

A

3-5 days later

39
Q

a close relative to the vaccinia virus used for smallpox vaccination

40
Q

commonly transmitted to farmworkers from cows

41
Q

Cowpox incubation period

A

9–10 days

42
Q

Cowpox virus can be distinguished from vaccinia virus by

A

deep red hemorrhagic lesions

43
Q

sheep and goat handlers

44
Q

cows (milker’s node)

A

Pseudocowpox

45
Q

benign epidermal tumor that occurs only in humans

A

Molluscum contagiosum

46
Q

oval or brickshaped and measures 230 × 330 nm; it resembles vaccinia

A

Molluscum contagiosum

47
Q

Africa, mainly in Kenya and the Democratic Republic of congo

48
Q

Tanapox natural host

49
Q

causes benign histiocytomas

A

Yaba monkey tumor poxvirus

MYCOLOGY AND VIROLOGY (5 decks)

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