Hep C Flashcards

1
Q

generalidades (3)

A
  • Hepacivirus (flavivirus)
  • RNA envuelto
  • virus no A no B
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2
Q

Mecanismos de patogenia (2)

A
  • virus se reviste de lipoproteinas y queda latente en el RE por gemación
  • INHIBE LA APOPTOSIS impidiendo muerte celular
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3
Q

Epidemiologia (2)

A
  • transmisión similar al HBV
  • mayor riesgo que Hep B de producir hepatitis crónicas
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4
Q

Transmisión

Horizontal (2)

A

población general

  • parenteral (2/3): uso compartido de jeringas contaminadas
  • sexual (1/3): MSM —> mayor riesgo, Saliva: no documentada
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5
Q

Transmisión

Vertical (4)

A
  • 1-5% de riesgo
  • mayor si existe confección materna con VIH
  • 20% resolución espontánea
  • 80% PROGRESAN A HEPATITIS CRÓNICA
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6
Q

Clínica

Periodo de incubación

A

14 a 180 días (45)

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7
Q

Clínica (4)

A
  • infección ASINTOMÁTICA en un 85%
  • infección sintomática en un 15%
  • 85% desarrollan cronicidad
  • clínicamente indistinguible de otras hepatitis
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8
Q

Clínica

Infección sintomática (5)

A
  • letargia
  • anorexia
  • nausea
  • vomito
  • dolor abdominal
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9
Q

Dx (2)

A
  • serológico (IgG)
  • molecular (carga viral, genotipo)
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10
Q

Tx

A

Depende del genotipo

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