HEMOLYTIC-UREMIC SYNDROME Flashcards
Definition
Recent exposure to Shiga-producing E. Coli 0157:H7
Acute Renal Failure
Thrombocytopenia
Microangiopathic Hemolytic Anemia
History & Physical
Nausea
Vomiting
Blood Diarrhea
Ask about:
Recent exposure to unpasturized milk, undercooked meat, contaminated produce
Ask about:
seizures
oliguria
Fatigue / pallor
confusion (encephalopathy)
Complications
Seizures
Renal Failure
Anemia
Encephalopathy
Investigations / Diagnosis
CBC: anemia (5-9), thrombocytopenia (<150,000)
PBC: schistocytes, helmet cells, burr cells
Stool Gram Stain, C & S, O&P for Shiga toxin and E.Coli 0157:H7
Management
Primarily Supportive
CIRCULATION:
Mild to Moderate Hypovolemia:
Oral Rehydration Solution
Goal: replace deficits over 4-6 hrs and replace ongoing losses
Mild - 1 ml / kg / 5 min
Moderate - 2 ml / kg / 5 min
Pedialyte:
45 mEq/L Sodium
140 mEq/L Glucose
Severe Hypovolemia:
IF dehydrated
20 ml / kg IV bolus NS over 15-20 min
Repeat until perfusion improves and urine output is adequate
THEN
Maintenance 4 cc / hr for 1st 10 kg, 2 cc / hr for 10-20 kg, 1 cc / hr per kg for every kg > 20 kg
D5 NS + 20 mEq/L KCL if isotonic dehydration
D5 1/2 NS + 20 mEq KCL if hypernatremic dehydration
MONITOR FOR FLUID OVERLOAD
No platelet transfusion
Antibiotics and Antiperistaltics are CONTRAINDICATED