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HEMATOLOGY - Lec > Hemolytic Anemia > Flashcards

Hemolytic Anemia Flashcards

1
Q

Primary underlying cause in hemolytic anemia

A

Hemolysis

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2
Q

Hemolytic anemia is classified as:

A

Acute vs chronic
Intrinsic vs extrinsic
Intravascular vs extravascular
Fragmentation vs macrophage mediated

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3
Q

Identify if acute or chronic hemolytic anemia:

Develops hemolytic crisis over time, causing anemia

A

Chronic hemolytic anemia

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4
Q

Identify if acute or chronic hemolytic anemia:

Rapid onset and isolated, episodic or paroxysmal

A

Acute hemolytic anemia

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5
Q

Identify if acute or chronic hemolytic anemia:

Thalassemia major

A

Chronic hemolytic anemia

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6
Q

Identify if acute or chronic hemolytic anemia:

Paroxysmal nocturnal hemoglobinuria

A

Acute hemolytic anemia

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7
Q

Identify if acute or chronic hemolytic anemia:

G6PD Deficiency

A

Chronic hemolytic anemia

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8
Q

Identify if acute or chronic hemolytic anemia:

Paroxysmal cold hemoglobinuria

A

Acute hemolytic anemia

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9
Q

Differenciate intrinsic and extrinsic hemolytic anemia.

A

Intrinsic - defect in the RBC membrane
Extrinsic - due to external factors

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10
Q

Subclassifications under intrinsic hemolytic anemia

A

Membrane defects
Enzyme defects
Hemoglobinopathies

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11
Q

Subclassifications under extrinsic hemolytic anemia

A

Immunohemolytic
Traumatic
Microangiopathic
Infectious agents
Chemical agents
Physical agents

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12
Q

What is the prominent product of RBC hemolysis

A

Bilirubin

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13
Q

What test for hemolytic anemia would cause a positive result even without a gross color change?

A

Urine blood strip test

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14
Q

What does spherocytes indicate in hemolytic anemia?

A

Macrophage mediated hemolysis

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15
Q

What are the tests used to identify specific hemolytic processes?

A

Direct antiglobulin test
Osmotic fragility test
Peripheral blood smear
Eosin-5’-maleimide binding test
Heinz body test

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16
Q

Protein mutation present in hereditary spherocytosis

A

Ankyrin
Band 3
a-spectrin
b-spectrin
Protein 4.2

17
Q

What receptor is present in macrophages that binds to Hgb-Hpt complex?

A

CD163

18
Q

What enzyme removes the iron from the hemoglobin?

A

Heme oxygenase

19
Q

Biliverdin is converted to unconjugated bilirubin by ______.

A

Biliverdin reductase

20
Q

The enzyme that adds two molecules of glucoronic acid to the unconjugated bilirubin to turn it into conjugated bilirubin.

A

UGT1A1

21
Q

What receptor is present in hepatocytes where unconjugated bilirubin binds to?

A

CD91

HEMATOLOGY - Lec (8 decks)

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