Anemia Of Abnormal Iron Metabolism Pt.2

Question 1

An acute phase reactant that is produced by the liver during inflammation in response to IL-6

Answer 1

Hepcidin

Question 2

An acute phase reactant that binds to iron in the granules of neutrophils

Answer 2

Lactoferrin

Question 3

Hepcidin and lactoferrin can result to _____

Answer 3

Functional iron deficiency

Question 4

Central feature of anemia of chronic inflammation

Answer 4

Sideropenia

Question 5

What does the lactoferrin do during a bacterial infection?

Answer 5

Lactoferrin transports the iron to the macrophage and the liver

Question 6

Diminished erythopoiesis causes what?

Answer 6

Production of cytokines
Leads to impairment of the proliferation of erythroid progenitor cells

Question 7

Laboratory diagnosis of anemia of chronic inflammation

Answer 7

Mild anemia
Hgb: 8-10 g/dL
No reticulocytosis
Normocytic, normochromic

Question 8

Treatment for anemia of chronic inflammation

Answer 8

EPO
Alleviation of underlying condition
Anti-hepcidin therapies

Question 9

What is the hallmark of sideroblastic anemia?

Answer 9

Ringed sideroblasts

Question 10

Certain drugs that may result to lead poisoning

Answer 10

Chloramphenicol
Isoniazid

Question 11

What does lead poisoning target?

Answer 11

ALA dehydratase

Question 12

Rbc indices in lead poisoning

Answer 12

Normocytic, normochromic

Question 13

Treatment for lead poisoning

Answer 13

Calcium disodium edetate

Question 14

Urine color in Porphyrias

Answer 14

Port wine

Question 15

Primary iron overload

Answer 15

Hereditary hemochromatosis

Question 16

Secondary iron overload

Answer 16

Chronic anemias and their treatment

Question 17

Iron overload effect on the liver

Answer 17

Liver cirrhosis

Question 18

d-Aminolevulenic acid synthase is associated with what disease?

Answer 18

Sideroblastic anemia

Question 19

is-Aminolevulenic acid Dehydratase is associated with what disease?

Answer 19

ALAD-deficient Porphyria

Question 20

Coproporphyrinogen oxidase is associated with what disease?

Answer 20

Hereditary Coproporphyria

Question 21

Lead poisoning is concerning because it affects what?

Answer 21

Central Nervous System
Hematologic system

Question 22

Lab diagnostic characteristics of Acquired Lead Poisoning

Answer 22

Normocytic, normochromic
Reticulocyte count = high
Basophilic stippling
BM: Erythroid hyperplasia

Question 23

Treatment for Lead Poisoning

Answer 23

Intake of Calcium disodium edetate

Question 24

Congenital Erythropoietic Porphyria affecta what enzyme?

Answer 24

Uroporphyrinogen III synthase deficiency

Question 25

BM appearance of a px with hereditary Porphyria

Answer 25

Bright red Erythroblasts under fluorescent microscope

Question 26

Considered as the true hereditary iron overload

Answer 26

Hemochromatosis

Question 27

The juvenile form of iron overload is associated with mutations of _____

Answer 27

Hepcidin or hemojuvelin genes

Question 28

Screening test for iron overload

Answer 28

Transferrin saturation, and serum ferritin test