Anemia Of Abnormal Iron Metabolism Pt.2 Flashcards
An acute phase reactant that is produced by the liver during inflammation in response to IL-6
Hepcidin
An acute phase reactant that binds to iron in the granules of neutrophils
Lactoferrin
Hepcidin and lactoferrin can result to _____
Functional iron deficiency
Central feature of anemia of chronic inflammation
Sideropenia
What does the lactoferrin do during a bacterial infection?
Lactoferrin transports the iron to the macrophage and the liver
Diminished erythopoiesis causes what?
Production of cytokines
Leads to impairment of the proliferation of erythroid progenitor cells
Laboratory diagnosis of anemia of chronic inflammation
Mild anemia
Hgb: 8-10 g/dL
No reticulocytosis
Normocytic, normochromic
Treatment for anemia of chronic inflammation
EPO
Alleviation of underlying condition
Anti-hepcidin therapies
What is the hallmark of sideroblastic anemia?
Ringed sideroblasts
Certain drugs that may result to lead poisoning
Chloramphenicol
Isoniazid
What does lead poisoning target?
ALA dehydratase
Rbc indices in lead poisoning
Normocytic, normochromic
Treatment for lead poisoning
Calcium disodium edetate
Urine color in Porphyrias
Port wine
Primary iron overload
Hereditary hemochromatosis
Secondary iron overload
Chronic anemias and their treatment
Iron overload effect on the liver
Liver cirrhosis
d-Aminolevulenic acid synthase is associated with what disease?
Sideroblastic anemia
is-Aminolevulenic acid Dehydratase is associated with what disease?
ALAD-deficient Porphyria
Coproporphyrinogen oxidase is associated with what disease?
Hereditary Coproporphyria
Lead poisoning is concerning because it affects what?
Central Nervous System
Hematologic system
Lab diagnostic characteristics of Acquired Lead Poisoning
Normocytic, normochromic
Reticulocyte count = high
Basophilic stippling
BM: Erythroid hyperplasia
Treatment for Lead Poisoning
Intake of Calcium disodium edetate
Congenital Erythropoietic Porphyria affecta what enzyme?
Uroporphyrinogen III synthase deficiency
BM appearance of a px with hereditary Porphyria
Bright red Erythroblasts under fluorescent microscope
Considered as the true hereditary iron overload
Hemochromatosis
The juvenile form of iron overload is associated with mutations of _____
Hepcidin or hemojuvelin genes
Screening test for iron overload
Transferrin saturation, and serum ferritin test
