Hemodynamics and Hemodynamic Measurements - Quiz 4 Flashcards
Velocity
distance per unit of time
Velocity is ___________ related to the cross-sectional area
Inversely
Flow
volume per unit of time
How to measure Blood Flow
Velocity x Cross Sectional Area
In Ohm’s Law, what 2 factors determine blood flow through a vessel?
1) Difference in Pressure
2) Resistance
Flow (Q) = (PA - PV) / R
What is Blood Pressure
The force exerted by blood against the vessel wall
1 mmHg = ? cm-H2O
1 mmHg = 1.36 cm-H2O
What is Poiseuille’s Law?
Poiseuille’s Law
Flow is directly proportional to the pressure gradient
Flow varies directly as the fourth power of the radius
o Doubling the radius of a tube causes a 16-fold increase in flow
Flow is inversely proportional to the viscosity of the fluid
Flow is inversely proportional to the length of the tube
Resistance = the impediment to blood flow in a vessel and cannot be measured by any direct means
What is Cerebral Perfusion Pressure
Cerebral Perfusion Pressure = MAP - CVP or ICP (whichever higher)
What has greatest impact on rate of bloow flow through a vessel wall regarding Poiseuille’s Law?
Diameter of Blood Vessel
What is Resistance?
The impediment of blood flow in a vessel - cannot be directly measured
SVR Formula
SVR = [(MAP - CVP) / CO] X 80
Normal: 700-1600
PVR Formula
PVR = [(MPAP - PCWP) / CO] x 80
Normal: 100 - 300
Calculating resistance in blood vessels arranged in a series
Total Resistance = Sum of Resistance of Each Vessel
Rt = R1 + R2 + R3 + R4
Calculating blood vessel resistance in Parallel Arrangement?
1/Rt = 1/R1 + 1/R2 + 1/R3
Parallel Arrangement allows for Local Blood Flow Regulation
What happens to total resistance if you added another blood vessel in a parallel arrangement?
Total resistance would decreases - another channel for blood to flow through
What is Laminar Flow
Fluid particles following moving in smooth paths in layers in a parallel
What is Turbulent flow?
Turbulent flow occurs when it fluids make sharp turn or passes over rough surface, becoming disorderly.
Blood flows crosswise in vessel and form local eddies, increasing flow resistance due to friction.
Formula used to predict laminar vs turbulent flow
Reynold’s Number (NR)
NR = pDv / n
p = density D = tube diameter v = velocity n = viscosity
Relationship of Hematocrit to Blood Viscosity?
Increasing Hematocrit increases Viscosity
Why does an increase in Blood Pressure cause a much greater increase in Blood Flow
Autoregulation. It is the intrinsic ability of an organ to maintain a constant blood flow despite changes in perfusion pressure.
What is the mechanism that drives blood flow?
The difference in total energy between two points
What are the three primary factors that determine blood flow resistance in a single vessel?
- Vessel Diameter - most important
- Vessel Length
- Viscosity of Blood