Heme Pharm Flashcards
Aspirin
MOA?
what does aspirin do to BT, PT and PTT,
irreversibly inhibits cyclooxygenase 1 and 2
permanently blocks conversion of arachidonic acids —–> thromboxane A2 (thus inhibit platelet aggregation.
BT prolonged
PT- , PTT -
NSAIDS inhibit the production of which substatnce important in platelet aggregationo?
Thromboxane A2
what is the mechanism of
streptokinase (fibrinolytic)
converts plasminogen to plasmin
which cleaves fibrin and breaks down clots
b
aspirin MOA
Irreversibly inhibits COX 1
clopidogrel MOA?
blcoks platelet ADP receptors
Abciximab moa
monoclonal antibody
binds to glycoprotein llb/llla
Tirofiban moa
inhibits glycoprotein llb/llla
Ticlopidine moa
blocks ADP receptors
Enoxaparin
moa
LMWH
inhibits factor Xa
Eptifibatide
moa
glycoprotein lla/lllb inhibitor
(also tirofiban and abciximab)
what drugs match this
MOA: phosphodiesterase inhibitors; inc cAMp in platelets, resulting in inhibition of platelet aggregation;
vasodilators
**** cilostazol
dipyridamole
what is the reverse agent for heparin
protamine sulfate
what is the reverse agent for thrombolytics
aka antifibrinolytic agent
aminocaproic acid
or
tranexamic acid
how do you monitor heparin in a pt
PTT
How do you monitoro warfarin use in a pt
PT (INR)
