heme

Question 1

what substances are known for causing hemolytic anemia in G6Pd def

“Spleen purges nasty inclusiong from damaged cells”

Answer 1

Sulfonamides

Primaquine

Nitrofrantoin

Isoniazid

Fava beans

Dapsone

Chloroquine (antimalarial)

Question 2

whats the life span of a platelet (including after transfusion)

Answer 2

8-10 days

Question 3

what molecule is expressed on the surface of a platelet after the platelet is activated by binding of ADP to P2Y12?

Answer 3

Gpllb/llla

Question 4

most common inherited coagulation (bleeding) disorder?

Answer 4

von Willebrand disease

Question 5

tx and diagnostic findings for

von willebrand disease

Answer 5

(DDAVP) Desmopressin

PT-, BT inc, .PT - , PTT -/ inc

use Ristocetin cofactor assay

if no VWF then no platelet aggregation.

Question 6

what platelet disorder

Anti-gpllb/llla antibodies

Answer 6

ITP

Question 7

what platelet disorder

ADAMTS -13 def

Answer 7

TTP

(DIT says alos HUS)

Question 8

what platelet disorder

gp lb defect

Answer 8

bernard-soulier syndrome

Question 9

what platelet disorder

gpllb/llla defect

Answer 9

Glanzmann’s thrombasthenia

Question 10

what platelet disorder

VWF defect

Answer 10

von willbrand disease

Question 11

what platelet disorder

wide spread activation of platelets and coagulation cascade

Answer 11

DIC

Question 12

what platelet diseases are chronic

Answer 12

genetic:

• VWD (Autosomal dom)
• Bernard soulier syndrome
• glanzmanns thrombasthenia

non-genetic: anti-gpllb/llla

Question 13

mc leukemia in children

Answer 13

ALL

Question 14

mc leukemia in adults in the us

Answer 14

CLL

Question 15

chracteristic Auer rods

Answer 15

AML

Question 16

MYELODYSPLASTIC syndromes have a tendency to progress to?

Answer 16

AML

Question 17

more than 20% blasts in the marrow indicates?

Answer 17

acute leukemia

Question 18

leukemia with more mature cells and < 5% blasts

Answer 18

chronic leukemia

Question 19

TdT (+) acute leukemia

Answer 19

ALL

Question 20

COMMONLY presents with BONE pain

Answer 20

ALL

Question 21

numerous basophils, splenomegaly

and negative for leukocyte alkaline phospahtes* (LAP)

Answer 21

CML

Question 22

always positive for the

Philadelphia chromosome t(9,22)

Answer 22

CML

Question 23

Acute leukemia postive for peroxidase (myeloperoxidase)

Answer 23

AML

Question 24

solid sheets of lymphoblasts in marrow

Answer 24

ALL

Question 25

always associated with the BCR-ABL gene

Answer 25

CML

Question 26

SMUDGE cells

Answer 26

CLL

Question 27

Reddish-pink rods in the Cytoplasm of leukemic blasts

Answer 27

Auer rods (AML)

Question 28

what disease is associated with these findings

punched out lytic bone lesions

Answer 28

multiple myeloma

Question 29

what disease is associated with these findings

RBCs clumped together like a stack of coins

Answer 29

Multiple myeloma

Question 30

what disease is associated with these findings

plethora + Pruritus + Headache

Answer 30

polycythemia vera

Question 31

HYPERcalcemia

back pain

anemia

renal insufficiency

Answer 31

Multiple myeloma

Question 32

what disease is associated with these findings

teardrop shaped RBCs

Answer 32

Myelofibrosis

Question 33

what disease is associated with these findings

monoclonal antibody spike

Answer 33

multiple myeloma

MGUS

Waldenstrom macroglobulinemia (no “CRAB” symptoms)

Question 34

pt is diagnosed with Multiple myeloma

what will be seen on urinalysis (UA)?

Answer 34

no proteinuria on routine urinalysis

must get UPEP to see monoclonal antibody spike..