heme Onc physio

Question 1

where do you see clock face chromatin?

Answer 1

plasma cells ( multiple myeloma)

Question 2

anisocytosis is

poikilocytosis is

Answer 2

varying sizes

varying shapes

Question 3

what does alpha granules contain? found in what cells

Answer 3

vwF , fibrinogen , fibronectin

thrombocytes

Question 4

1/3 of the platlet pool is stored in

Answer 4

spleen

Question 5

dense granules have

Answer 5

ADP, Calcium

found in thrombocytes

Question 6

neutrophils has 2 types of granules sho hene and what do they contain

Answer 6

specific granules : LAP - collagenase - lysozymes - lactoferrin
azurophilic granules ( lysosomes): proteinases , acid phosphatase, myeloperoxidase , beta glucuronidase

Question 7

neutrophilic chemotactic :

Answer 7

C5A , IL8 , LTB4 , kallikrein , platlet-activating factor

Question 8

sho esem el macrophages in CT ?

Answer 8

histiocytes

Question 9

lipid A from bacterial LPS binds to what on macrophages?

Answer 9

CD14

Question 10

what is the shape of the eosinophils

Answer 10

bilobate nucleus

Question 11

basophilic granules in basophils contain

where do we see basophilia?

Answer 11

heparin and histamine

CML

Question 12

what are dendritic cells? what do they express? sho esmon bil skin?

Answer 12

• highly phagocytic
• express MHC II and Fc receptors on surface
• langerhans cells in the skin

Question 13

Most circulating lymphocytes are

Answer 13

Tcells (80%)

Question 14

mneumonic of fetal erythropoiesis

Answer 14

young liver synthesize blood

Question 15

hemoglobin electrophoresis

Answer 15

A fat santa claus ( C S F A ) (c)athode to anode

Question 16

HbS and HbC are what type of mutation?

replace what with what

Answer 16

missense mutation
they replace glutamic acid with valine(neutral) in HbS
they replace glutamine acid with lysine(positively charged) in HbC

Question 17

which cell 3nda abundant RER and well developed golgi apparatus

Answer 17

plasma cell

Question 18

bradykinin causes

Answer 18

VPP
Vasodilation
increase in permeability
increase in pain

Question 19

what is the hereditary in hemophilia A , B , C

Answer 19

A and B and XR

C is AR

Question 20

shortest half life coagulation factor is

Answer 20

Factor VII (7)

Question 21

longest halflife coagulation factor

Answer 21

factor II

Question 22

protein C inactivates

Answer 22

58 ( fakre eza ensete eno eza zedna C la 5 men fo2 w men tahet btsir number 8 )

Question 23

FFP or PCC administration for action of warfarin. PCC is what

Answer 23

prothrombin complex concentrate

Question 24

what does activated protein C do ? ( 2 things)

Answer 24

1) inactivates 5 and 8

2) inhibits tPa inhibitor . relieving tPa inhibition –> free and tPa changes plasminogen to plasmin

Question 25

Antithrombin inhibits activation of

Answer 25

2, 7, 9, 10, 11, 12

Question 26

vWF from where byeje

Answer 26

weibel palade bodies of endothelial cells and alpha granules of platlets

Question 27

steps of platlet pllug formation

Answer 27

injury--> exposure--> adhesion --> activation --> aggregation

Question 28

thrombocytes contain what granules

Answer 28

dense granules and alpha granule s

Question 29

what cancer can lead to anticoagulation ?

Answer 29

Prostate Ca --> secreates urokinase.