heme Onc physio Flashcards
where do you see clock face chromatin?
plasma cells ( multiple myeloma)
anisocytosis is
poikilocytosis is
varying sizes
varying shapes
what does alpha granules contain? found in what cells
vwF , fibrinogen , fibronectin
thrombocytes
1/3 of the platlet pool is stored in
spleen
dense granules have
ADP, Calcium
found in thrombocytes
neutrophils has 2 types of granules sho hene and what do they contain
specific granules : LAP - collagenase - lysozymes - lactoferrin azurophilic granules ( lysosomes): proteinases , acid phosphatase, myeloperoxidase , beta glucuronidase
neutrophilic chemotactic :
C5A , IL8 , LTB4 , kallikrein , platlet-activating factor
sho esem el macrophages in CT ?
histiocytes
lipid A from bacterial LPS binds to what on macrophages?
CD14
what is the shape of the eosinophils
bilobate nucleus
basophilic granules in basophils contain
where do we see basophilia?
heparin and histamine
CML
what are dendritic cells? what do they express? sho esmon bil skin?
- highly phagocytic
- express MHC II and Fc receptors on surface
- langerhans cells in the skin
Most circulating lymphocytes are
Tcells (80%)
mneumonic of fetal erythropoiesis
young liver synthesize blood
hemoglobin electrophoresis
A fat santa claus ( C S F A ) (c)athode to anode
HbS and HbC are what type of mutation?
replace what with what
missense mutation
they replace glutamic acid with valine(neutral) in HbS
they replace glutamine acid with lysine(positively charged) in HbC
which cell 3nda abundant RER and well developed golgi apparatus
plasma cell
bradykinin causes
VPP
Vasodilation
increase in permeability
increase in pain
what is the hereditary in hemophilia A , B , C
A and B and XR
C is AR
shortest half life coagulation factor is
Factor VII (7)
longest halflife coagulation factor
factor II
protein C inactivates
58 ( fakre eza ensete eno eza zedna C la 5 men fo2 w men tahet btsir number 8 )
FFP or PCC administration for action of warfarin. PCC is what
prothrombin complex concentrate
what does activated protein C do ? ( 2 things)
1) inactivates 5 and 8
2) inhibits tPa inhibitor . relieving tPa inhibition –> free and tPa changes plasminogen to plasmin
Antithrombin inhibits activation of
2, 7, 9, 10, 11, 12
vWF from where byeje
weibel palade bodies of endothelial cells and alpha granules of platlets
steps of platlet pllug formation
injury–> exposure–> adhesion –> activation –> aggregation
thrombocytes contain what granules
dense granules and alpha granule s
what cancer can lead to anticoagulation ?
Prostate Ca –> secreates urokinase.
