Heme/ONC

Question 1

Von Willebrand dz, Protein C def, hemophilia A & B

PTT, PT, bleeding time, platelets?

Answer 1

• VWD: normal platelets, PT/INR & aPTT
• Hemophilia A/B: nomal platelets, PT, bleeding time. Prolonged PTT
• Protein C: def causes DIC = prolonged bleeding time, low platelets & increased PT & PTT

Question 2

When do you see Howell jolly bodies?

Answer 2

Howel jolly = nuclear remnants/DNA. Seen anytime you have significant reticulocytosis.
-aspleenia, spleen trauma,autospleenectomy/sickle cell anemia, megaloblastic anemia, hereditary spherocytosis, myelodysplastic syndrome

Question 3

When do you see basophilic stippling? what is it?

Answer 3

Basophilic stipling is aggregation of residual ribosomes = toxic injury to bone marrow such as in lead poisoning or megaloblastic anemia.

Question 4

When do you see burr cells?

Answer 4

occurs when RBC have abnormal cell membranes.

Question 5

When do you see Heinz bodies? what are they?

Answer 5

denatured globin chains within RBC. seen with G6PD deficiency

Question 6

Beta Thalassemia hemoglobin electrophoresis will show….

Answer 6

Reduced or absent HgAlpha, increased HgA2 and increase HgF