Heme Onc

Question 1

Chronic myeloproliferative disorders (polycythemia vera, essential thrombocytosis, primary myelopfibrosis)

Answer 1

Often hav mutation in JAK2, a cytoplasmic tyrosine kinase. Constitutive TK activity and and consequently cytokine-independent activation of signal transducers and activators of transcription (STAT) proteins

Question 2

Aplastic crisis

Answer 2

In sickle cell patients usually due to parvovirus B19 infection of erythroid precursor cells in the bone marrow. Destruction of erythroid precursor cells by the virus, diminishes the number of reticulocytes available to replace the deformed and/or removed erythrocytes.

Presents w anemia