Heme/Onc

Question 1

Auer Rods

Answer 1

AML

Question 2

Philly Chromosome 9:22

Answer 2

CML

Question 3

Sickle Cell Trait patients commonly get…

Answer 3

Hematuria secondary to renal papillary necrosis

Question 4

Burkitt Lymphoma

Answer 4

t(8,14) c-myc Sporadic Burkitt Lymphoma is seen in Western Hemisphere: abdominal mass, ascites, tumor lysis syndrome with elevated LDH + uric acid Endemic Burkitt Lymphoma is seen in Africa: jaw/facial tumors with extranodal spread to other organs

Question 5

Multiple myeloma - most common finding on echocardiography

Answer 5

decreased stroke volume secondary to excessive protein buildup causing restrictive cardiomyopathy

Question 6

Small Cell Lung Ca. keywords

Answer 6

large hilar mass (central nodular lesion) bilat hilar adenopathy smoking

Hypercortisol

HypOnatremia

Question 7

Papillary thyroid ca. _____ of all thyroid ca.

Answer 7

74-80%

Question 8

Trisomy 21 is associated with an increased risk of

Answer 8

ALL

Question 9

Von Willebrand Disease Lab

Answer 9

Inc. PTT Inc. BT

Question 10

Hairy Cell Leukemia keywords

Answer 10

TRAP+ splenomegaly + pancytopenia Tx: Nucleoside analogs

Question 11

Squamous cell ca. associated risk factor? Produces what? Located where?

Answer 11

Smoking

Hilar (centrally located)

PTHrP –> hypercalcemia

Question 12

Fanconi Anemia Inheritance? D/t? Tx?

Answer 12

S&S: aplastic anemia, abnormal thumbs, cafe au lait, large freckles, deafness AutoRec. d/t chromosomal breaks on genetic analysis Tx: Hematopoietic stem cell transplant

Question 13

DIC labs

Answer 13

Decreased Fibrinogen, Factor II, V, VIII, platelets Increased PT/PTT, D-dimer

Question 14

Graft-Versus-Host Disease Tx?

Answer 14

maculopapular rash, GI symptoms, hepatic dysfunction in a pt. who recently underwent a transplant Methylprednisolone (suppresses cytokine release)

Question 15

Labs in B12 Deficiency

Answer 15

Inc. MMA Inc. Homocysteine

Question 16

Labs in Folate Deficiency

Answer 16

Inc. Homocysteine

Question 17

Tx. for AML puts patients at risk for?

Answer 17

Tumor Lysis Syndrome: hyperkalemia/phosphatemia/uricemia/

Question 18

Tx. Beta Thal Major

Answer 18

Packed RBC transfusions

Question 19

Ependymoma Tx

Answer 19

Surgery then radiotherapy (Lumbar Puncture is contraindicated due to risk of herniation.)

Question 20

Rituximab MOA Tx for what diseases?

Answer 20

Anti-B cell med Tx for: B cell lymphoma, CLL, ITP, RA, Refractory Lupus Nephritis, Waldenstrom’s, Wegener’s (granulomatosis w/ polyangiitis)

Question 21

Cyclosporine MOA

Answer 21

IL-2 Inhibitor Tx for Solid organ transplant

Question 22

Tx. for Acute DVT

Answer 22

IV Heparin (not SQ)

Question 23

Coagulation Cascade

Answer 23

Question 24

What is thrombopoietin?

What is it’s level in Polycythemia Vera?

Answer 24

Megakaryocyte growth factor.

Thrombopoietin is decreased in P-vera because since body’s making a lot of erythroid precursors, it’s also making a lot of platelet precursors, thereby negative feedbacking on thrombopoietin to decrease it.

Question 25

Heparin’s MOA?

Effects on coagulation cascade?

Answer 25

activates Antithrombin III, affecting Intrinsic Pathway (PITT)

↑ PTT

Question 26

Coumadin’s MOA?

Effects on coagulation cascade?

Answer 26

Inhibits Vit. K (2, 7, 9, 10, C, S), affects Extrinsic Pathway (PET)

↑ PT

Question 27

LMWH’s MOA?

Effects on coagulation cascade?

Answer 27

Inhibits Factor Xa

Question 28

Antiphospholipid Syndrome (Hughes Syndrome)

Question 29

Hemophilia

Tx?

Answer 29

Concentrated Factor 8

Cryoprecipitate (contains Factor 8, Fibrinogen, Fibronectin, Factor 13, and vWF)

DDAVP (for MILD hemophilia)

Question 30

Idiopathic Thrombocytopenic Purpura (ITP)

Answer 30

Often young children with isolated thrombocytopenia

Tx: Glucocorticoids and IV Ig

Question 31

Thrombotic Thrombocytopenic Purpura (TTP) keywords

Answer 31

Thrombocytopenia

Anemia

Renal Failure

Seizures, Altered mental status

Question 32

Adenocarcinoma keywords

Answer 32

women

non-smoking

peripheral