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COMLEX 2 > Heme/Onc > Flashcards

Heme/Onc Flashcards

1
Q

Auer Rods

A

AML

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2
Q

Philly Chromosome 9:22

A

CML

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3
Q

Sickle Cell Trait patients commonly get…

A

Hematuria secondary to renal papillary necrosis

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4
Q

Burkitt Lymphoma

A

t(8,14) c-myc Sporadic Burkitt Lymphoma is seen in Western Hemisphere: abdominal mass, ascites, tumor lysis syndrome with elevated LDH + uric acid Endemic Burkitt Lymphoma is seen in Africa: jaw/facial tumors with extranodal spread to other organs

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5
Q

Multiple myeloma - most common finding on echocardiography

A

decreased stroke volume secondary to excessive protein buildup causing restrictive cardiomyopathy

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6
Q

Small Cell Lung Ca. keywords

A

large hilar mass (central nodular lesion) bilat hilar adenopathy smoking

Hypercortisol

HypOnatremia

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7
Q

Papillary thyroid ca. _____ of all thyroid ca.

A

74-80%

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8
Q

Trisomy 21 is associated with an increased risk of

A

ALL

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9
Q

Von Willebrand Disease Lab

A

Inc. PTT Inc. BT

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10
Q

Hairy Cell Leukemia keywords

A

TRAP+ splenomegaly + pancytopenia Tx: Nucleoside analogs

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11
Q

Squamous cell ca. associated risk factor? Produces what? Located where?

A

Smoking

Hilar (centrally located)

PTHrP –> hypercalcemia

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12
Q

Fanconi Anemia Inheritance? D/t? Tx?

A

S&S: aplastic anemia, abnormal thumbs, cafe au lait, large freckles, deafness AutoRec. d/t chromosomal breaks on genetic analysis Tx: Hematopoietic stem cell transplant

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13
Q

DIC labs

A

Decreased Fibrinogen, Factor II, V, VIII, platelets Increased PT/PTT, D-dimer

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14
Q

Graft-Versus-Host Disease Tx?

A

maculopapular rash, GI symptoms, hepatic dysfunction in a pt. who recently underwent a transplant Methylprednisolone (suppresses cytokine release)

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15
Q

Labs in B12 Deficiency

A

Inc. MMA Inc. Homocysteine

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16
Q

Labs in Folate Deficiency

A

Inc. Homocysteine

17
Q

Tx. for AML puts patients at risk for?

A

Tumor Lysis Syndrome: hyperkalemia/phosphatemia/uricemia/

18
Q

Tx. Beta Thal Major

A

Packed RBC transfusions

19
Q

Ependymoma Tx

A

Surgery then radiotherapy (Lumbar Puncture is contraindicated due to risk of herniation.)

20
Q

Rituximab MOA Tx for what diseases?

A

Anti-B cell med Tx for: B cell lymphoma, CLL, ITP, RA, Refractory Lupus Nephritis, Waldenstrom’s, Wegener’s (granulomatosis w/ polyangiitis)

21
Q

Cyclosporine MOA

A

IL-2 Inhibitor Tx for Solid organ transplant

22
Q

Tx. for Acute DVT

A

IV Heparin (not SQ)

23
Q

Coagulation Cascade

A
24
Q

What is thrombopoietin?

What is it’s level in Polycythemia Vera?

A

Megakaryocyte growth factor.

Thrombopoietin is decreased in P-vera because since body’s making a lot of erythroid precursors, it’s also making a lot of platelet precursors, thereby negative feedbacking on thrombopoietin to decrease it.

25
Q

Heparin’s MOA?

Effects on coagulation cascade?

A

activates Antithrombin III, affecting Intrinsic Pathway (PITT)

↑ PTT

26
Q

Coumadin’s MOA?

Effects on coagulation cascade?

A

Inhibits Vit. K (2, 7, 9, 10, C, S), affects Extrinsic Pathway (PET)

↑ PT

27
Q

LMWH’s MOA?

Effects on coagulation cascade?

A

Inhibits Factor Xa

28
Q

Antiphospholipid Syndrome (Hughes Syndrome)

A
29
Q

Hemophilia

Tx?

A

Concentrated Factor 8

Cryoprecipitate (contains Factor 8, Fibrinogen, Fibronectin, Factor 13, and vWF)

DDAVP (for MILD hemophilia)

30
Q

Idiopathic Thrombocytopenic Purpura (ITP)

A

Often young children with isolated thrombocytopenia

Tx: Glucocorticoids and IV Ig

31
Q

Thrombotic Thrombocytopenic Purpura (TTP) keywords

A

Thrombocytopenia

Anemia

Renal Failure

Seizures, Altered mental status

32
Q

Adenocarcinoma keywords

A

women

non-smoking

peripheral

COMLEX 2 (19 decks)

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