Common Antibody keywords in Diseases

Question 1

anti-dsDNA, anti-Smith

Answer 1

“flea-bitten” appearance on the cortical surface of the kidney (SLE)

Question 2

Anti-citrullinated peptide/protein antibodies (CCP)

Answer 2

Elevated in a patient with distal interphalangeal hyper flexion and proximal interphalangeal hyperextension (RA)

Question 3

Anti-Scl 70/Antinuclear/Antitopoisomerase Abs

Answer 3

Decreased respiratory ventilation and diffusing capacity for carbon monoxide as well as occasional skin discoloration in the fingertips (scleroderma)

Question 4

Anti-U1 ribonucleoprotein antibody

Answer 4

Causes myalgias, skin color variation with temperature change and hypergammaglobinemia (Mixed Connective Tissue Disease)

Question 5

Anti-Ro/SSA antibody

Answer 5

Causes slow heart rate with intermittent cannon waves in the neck in a neonate (Neonatal Lupus)

Question 6

ANA

Answer 6

SLE

Question 7

Anti-Centromere

Answer 7

CREST

Question 8

Anti-Histone

Answer 8

SLE (Drug induced)

Question 9

Anti-Jo-1

Answer 9

Polymyositis & Dermatomyositis

Question 10

Antimitochondrial Abs

Answer 10

Primary Biliary Cirrhosis (PBC)

Question 11

Anti-smooth muscle Abs

Answer 11

Auto-immune Hepatitis

Question 12

Anti-TSH-R

Answer 12

Graves’ Disease

Question 13

c-ANCA

Answer 13

Wegener’s

Question 14

p-ANCA

Answer 14

Microscopic Polyangiitis & Churg-Strauss

Question 15

Anti-thyroglobulin, Anti-TPO Abs

Answer 15

Hashimoto’s Thyroiditis (autoimmune hypothyroidism)