Heme Onc Flashcards

1
Q

Ewing sarcoma

A

Soft tissue

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2
Q

Osteogenic sarcoma

A

More common in blacks
Teenager with growth spurt
Proximal, distal long bones (femur, humerus)

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3
Q

Osteoid osteoma

A

Tibia, femur pain
Relieved with NSAIDs
Worse at night
Central radiolucent, surrounded by sclerotic

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4
Q

Hodgkins lymphoma

A
Teenager
Nontender cervical nodes
Weight loss, fever, night sweats
Reed Sternberg cells
High WBCs, low lymphocytes
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5
Q

Non Hodgkins lymphoma

A

Small chiild

Had/neck, abdominal mass

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6
Q

Langerhans cell histiocytosis

A
Seborrheic rash
Ear discharge
Lytic skull lesions
Diabetes insipidus
Excessive urination

Dx: skin Bx, electron microscope

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7
Q

Neuroblastoma

A

MC solid tumor
Survival rate 95% if < 12 mos

Nontender abdominal mass
Weight loss, anorexia
Racoon eyes
Horner syndrome
Irritability, hypertension, diarrhea

Dx: urine VMA, HMA

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8
Q

Wilms tumor

A
Toddler
Asymptomatic abdominal mass
Hematuria
Hemihypertrophy
Beckwith Wiedeman syndrome
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9
Q

Cyclophosphamide

A

Hemorrhagic cystitis

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10
Q

Bleomycin

A

Pulmonary fibrosis

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11
Q

Anthracycline
Doxorubicin
Daunorubicin

A

Cardiac toxicity

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12
Q

Vincristine/Vinblastine

A

Neurotoxicity

SIADH

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13
Q

Asparaginase

A

Pancreatitis

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14
Q

Procarbazine

A

CNS problems

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15
Q

Methotrexate

A

Oral, GI ulcers

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16
Q

Ifosphamide

A

Nephrotoxicity

17
Q

Physiologic anemia

A

2nd/3rd mo (8-10 wks)
Low erythropoietin production
Normal MCV 70-90

18
Q

Beta Thalassemia

A

Mediterranean
Hepatosplenomegaly
Increased Hb A2, F
Hair on end appearance on skull XR

Cx: cholelithiasis, hemosiderosis

19
Q

Macrocytic anemia

A

B12 deficiency
Folate deficiency
Fanconi anemia
Blackfan anemia

20
Q

B12 deficincy

A

Bacterial overgrowth
Bowel resection
B12 deficiency
HLA B27 (Crohns)

Dx: Schilling test

21
Q

B12 deficiency

A

Weakness
Paresthesia
Sore tongue

22
Q

Folate deficiency

A

Erythrocyte folic acid concentration

R/ B12 deficiency

23
Q

G6PD deficincy

A

Heinz bodies
Dark urine, jaundice, anemia
Mothballs, antimalarials, nitrofurantoin

A: African Americans
B: Mediterranean

24
Q

Hereditary spherocytosis

A

Autosomal dominant

Increased MCHC
Spectrin deficiency
Hemolytic anemia

Tx: folic acid

25
Q

Pyruvate kinase deficiency

A

Autosomal recessive
Normal osmotic fragility
Hemolytic anemia

26
Q

Fanconi anemia

A
Short stature
Cafe au lait
Absent thumb, radius
Cardiac defects
Pancytopenia
Leukemia, malignancy risk
Chromosomal breakage
27
Q

Transient Erythroblastopenia of Childhood

A

Toddler
Normal MCV, reticulocytopenia
Spontaneous recovery

28
Q

Mediastinal mass

A

Anterior: lymphoma

Posterior: neuroblastoma, Ewings