Heme Onc Flashcards
Ewing sarcoma
Soft tissue
Osteogenic sarcoma
More common in blacks
Teenager with growth spurt
Proximal, distal long bones (femur, humerus)
Osteoid osteoma
Tibia, femur pain
Relieved with NSAIDs
Worse at night
Central radiolucent, surrounded by sclerotic
Hodgkins lymphoma
Teenager Nontender cervical nodes Weight loss, fever, night sweats Reed Sternberg cells High WBCs, low lymphocytes
Non Hodgkins lymphoma
Small chiild
Had/neck, abdominal mass
Langerhans cell histiocytosis
Seborrheic rash Ear discharge Lytic skull lesions Diabetes insipidus Excessive urination
Dx: skin Bx, electron microscope
Neuroblastoma
MC solid tumor
Survival rate 95% if < 12 mos
Nontender abdominal mass Weight loss, anorexia Racoon eyes Horner syndrome Irritability, hypertension, diarrhea
Dx: urine VMA, HMA
Wilms tumor
Toddler Asymptomatic abdominal mass Hematuria Hemihypertrophy Beckwith Wiedeman syndrome
Cyclophosphamide
Hemorrhagic cystitis
Bleomycin
Pulmonary fibrosis
Anthracycline
Doxorubicin
Daunorubicin
Cardiac toxicity
Vincristine/Vinblastine
Neurotoxicity
SIADH
Asparaginase
Pancreatitis
Procarbazine
CNS problems
Methotrexate
Oral, GI ulcers