Hematopoietic stem cell transplantation in clinical practice Flashcards

1
Q

Why allogeneic transplantation?

A

To replace absent, defective, or damaged hematopoietic immune system. Or to elicit a graft-versus-tumor effect.

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2
Q

What is autologous stem cell therapy?

A

Autologous SCT is myeloablative therapy where they have patients’ stem cells as rescue and the treatment is chemotherapy.

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3
Q

What is allogeneic stem cell therapy?

A

Allogeneic SCT is mild or myeloablative therapy where they have donor stem cells as rescue and the treatment is chemotherapy and immunotherapy.

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4
Q

What is the mechanism of graft-versus-leukmia effect?

A

Host dendritic cells (DCs), activated by CD4-positive T cells, mature and can then activate CD8-positive T cells via a “license to kill” and attack leukemia cells. The leukemia cells themselves can also differentiate into self DC.

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