Animal models for Celiac disease Flashcards
1
Q
How is autoimmunity against food antigens suppressed?
A
By Treg cells with regulation of Foxp3.
2
Q
How is autoimmunity against gluten suppressed?
A
By Tr1-like cells that secrete IL-10 but do not express Foxp3.
3
Q
What does the absence of IL-10 signaling in CD11c+ APCs cause?
A
A Celiac disease-like pathology: crypt hyperplasia, increased IEL numbers, and increased number of CD4+ and CD8+ T cells in the lamina propria.
