Dendritic cells and Tolerance

Question 1

What are the receptors on tolerogenic cells?

Answer 1

Checkpoint molecules (PDL1), secretion of IL-10, and decrease in co-stimulatory molecules (CD80/CD86).

Question 2

How does the administration of tolerogenic DCs for treatment work?

Answer 2

Blood is taken from the patients and monocytes are isolated. Then tolerogenic DCs are generated with chemical induction (e.g. vitD3) and re-administered to the patient.

Question 3

What is the downside of administration of tolerogenic DCs?

Answer 3

It is personalized so it is laborious and costly.

Question 4

What are Siglecs?

Answer 4

They are sialic acid binding immunoglobulin type lectins, that can cause immune inhibition, immune activation or have no signaling motif.

Question 5

How can sialic acids induce tolerance?

Answer 5

Sialic acid coupled to an antigen induces regulatory T cells and diminishes effector T cells.