Hematopoiesis Flashcards
fetal hematopoiesis occurs in
- yolk sac
- liver
- spleen
- bone
young liver synthesizes blood
where does hematopoiesis occur in adults
- axial skeleton
- proximal long bones
essential components of hematopoiesis
- stem cells
- stromal
- growth factors
stromal
- fat cells
- macrophages
- endothelial cells
- fibroblasts
what do non-lineage specific growth factors act on
- pluripotent and multipotent stem cells
- to initiative self-renewal and differentiation
non-lineage specific growth factors examples
- IL-3
- GM-CSF
what do lineage specific growth factors act on
- committed progenitor cells involved in differentiation and maturation of blood cells
lineage specific growth factors examples
- G-CSF
- M-CSF
- IL-5
- EPO
- TPO
self renewal
- proliferate to produce more stem cells
differentiation
- produce highly specialized mature cell types
- then produce more developmentally restricted cells (progenitor cells)
multipotent cell
- can differentiate into lymphoid cells or myeloid cells
lymphoid cell examples
- dendritic cells
- B cell
- T cell
- NK cell
myeloid cell examples
- neutrophil
- macrophage
- eosinophil
- basophil
- mast cell
progenitor cels
- committed to a cell lineage
precursor cels
- develop into mature cells of the various cell types
- exhibit morphological characteristics specific to their lineage
erythropoiesis process
- proerythroblast
- basophilic erythroblast
- polychromatophilic erythroblast
- orthochromatophilic erythroblast
- reticulocyte
- mature RBC
which cell in erythropoiesis process is last stage capability of division
- polychromatophilic erythroblast
granulopoiesis process
- myeloblast
- promyelocyte
- myelocyte
- metamyelocyte
- band neutrophil
- mature neutrophil
which stage of granulopoiesis process is the last stage of mitotic division
- myelocyte
monocytopoiesis process
- monoblast
- monocyte
- macrophages or histiocytes
megakaryocytopoiesis
- megakaryocytes mature into multi lobed giant cells
- cytoplasm becomes granular and released into bone marrow in long platelet
myeloid cells versus erythroid cells in normal adult bone marrow
- more myeloid cells than erythroid cells
aspiration
- needle inserted into marrow
- liquid sample sucked into syringe
biopsy
- provides solid core of bone marrow
- examined as histological specimen after fixation
