Hematopoiesis

Question 1

fetal hematopoiesis occurs in

Answer 1

• yolk sac
• liver
• spleen
• bone

young liver synthesizes blood

Question 2

where does hematopoiesis occur in adults

Answer 2

• axial skeleton

- proximal long bones

Question 3

essential components of hematopoiesis

Answer 3

• stem cells
• stromal
• growth factors

Question 4

stromal

Answer 4

• fat cells
• macrophages
• endothelial cells
• fibroblasts

Question 5

what do non-lineage specific growth factors act on

Answer 5

• pluripotent and multipotent stem cells

- to initiative self-renewal and differentiation

Question 6

non-lineage specific growth factors examples

Answer 6

• IL-3

- GM-CSF

Question 7

what do lineage specific growth factors act on

Answer 7

• committed progenitor cells involved in differentiation and maturation of blood cells

Question 8

lineage specific growth factors examples

Answer 8

• G-CSF
• M-CSF
• IL-5
• EPO
• TPO

Question 9

self renewal

Answer 9

• proliferate to produce more stem cells

Question 10

differentiation

Answer 10

• produce highly specialized mature cell types

- then produce more developmentally restricted cells (progenitor cells)

Question 11

multipotent cell

Answer 11

• can differentiate into lymphoid cells or myeloid cells

Question 12

lymphoid cell examples

Answer 12

• dendritic cells
• B cell
• T cell
• NK cell

Question 13

myeloid cell examples

Answer 13

• neutrophil
• macrophage
• eosinophil
• basophil
• mast cell

Question 14

progenitor cels

Answer 14

• committed to a cell lineage

Question 15

precursor cels

Answer 15

• develop into mature cells of the various cell types

- exhibit morphological characteristics specific to their lineage

Question 16

erythropoiesis process

Answer 16

• proerythroblast
• basophilic erythroblast
• polychromatophilic erythroblast
• orthochromatophilic erythroblast
• reticulocyte
• mature RBC

Question 17

which cell in erythropoiesis process is last stage capability of division

Answer 17

• polychromatophilic erythroblast

Question 18

granulopoiesis process

Answer 18

• myeloblast
• promyelocyte
• myelocyte
• metamyelocyte
• band neutrophil
• mature neutrophil

Question 19

which stage of granulopoiesis process is the last stage of mitotic division

Answer 19

• myelocyte

Question 20

monocytopoiesis process

Answer 20

• monoblast
• monocyte
• macrophages or histiocytes

Question 21

megakaryocytopoiesis

Answer 21

• megakaryocytes mature into multi lobed giant cells

- cytoplasm becomes granular and released into bone marrow in long platelet

Question 22

myeloid cells versus erythroid cells in normal adult bone marrow

Answer 22

• more myeloid cells than erythroid cells

Question 23

aspiration

Answer 23

• needle inserted into marrow

- liquid sample sucked into syringe

Question 24

biopsy

Answer 24

• provides solid core of bone marrow

- examined as histological specimen after fixation