Approach to the Anemic Patient Flashcards

1
Q

hemoglobin is a measurement of

A
  • concentration of hemoglobin
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2
Q

hemoglobin type of measurement

A
  • direct measurement
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3
Q

hematocrit is a measurement of

A
  • volume of red cells per volume of blood

- given as a percentage

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4
Q

hematocrit type of measurement

A
  • calculated value
  • Hit = RBC x MCV

height of red cells divided by total height of the liquid in the tube

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5
Q

hematocrit compared to hemoglobin

A
  • generally Hct is 3x hemoglobin
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6
Q

RBC type of measurement

A
  • direct measurement
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7
Q

MCV is a measurement of

A
  • red cell volume

- how big the red blood cells are

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8
Q

MCV type of measurement

A
  • direct measurement
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9
Q

RDW measurement of

red cell distribution of width

A
  • how much spread there is in MCVs of different red cells in patient’s body
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10
Q

iron deficiency cells change in RDW

A
  • RDW gets wider
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11
Q

microcytic cells then transfusion - change in RDW

A
  • RDW gets wider
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12
Q

anemia definition

A
  • a decreased hemoglobin/hematocrit below the normal range for gender and age
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13
Q

anemia (manifestation of disease versus final diagnosis)

A
  • anemia is a manifestation of disease not a final diagnosis
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14
Q

anemia leads to

A
  • reduction of oxygen carrying capacity
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15
Q

acute blood loss leads to

A
  • low blood volume
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16
Q

chronic, longstanding anemia leads to

A
  • fluid retention

- increased blood volume

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17
Q

faster rate of change of hemoglobin will lead to

A
  • more dramatic symptoms
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18
Q

if an anemic person is volume overloaded, but needs a transfusion, what do you do?

A
  • give a diuretic first
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19
Q

most symptoms of acute hemorrhage in anemia related to

A
  • hypovolemia
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20
Q

symptoms of hypovolemia

A
  • hypotension
  • orthostatic changes
  • syncope
  • shock
21
Q

symptoms of tissue hypoxia

A
  • fatigue
  • shortness of breath
  • cognitive difficulties
  • ischemic pain
22
Q

cardiac response to anemia

A
  • increased heart rate

- increased cardiac output

23
Q

vascular response to anemia due to acute blood loss and hypovolemia

A
  • vasoconstriction
24
Q

kidney response to chronic anemia

A
  • retain salt and water to expand intravascular volume
25
erythrocyte 2,3-DPG response to chronic anemia
- increased - right shift in O2 curve - increased O2 delivery to tissues
26
renal mesangial cells response to chronic anemia
- sense decreased oxygen deliverty | - increase erythropoietin synthesis
27
mechanisms by which anemia can occur
- hemorrhage - decreased red cell survival - decreased red cell production
28
ways to classify anemia
- by erythropoietic response | - by red cell size and hemoglobin concentration
29
erythropoietic response
- hyperproliferative | - hypoproliferative
30
hyperproliferative
- plenty of reticulocytes | - problem due to loss or destruction of reticulocytes
31
hypoproliferative
- not enough reticulocytes
32
red cell size and hemoglobin concentration classification
- microcytic, hypochromic - macrocytic - normocytic, normochromic
33
reticulocyte definition
- young red cells immediately released by the bone marrow as the end result of erythropoiesis
34
reticulocyte on Wright-Giemsa staining
- polychromatophilic (grayish blue)
35
reticulocyte composition
- RNA remnants on supra vital staining | - reticulated
36
absolutely reticulocyte count formula
- retic (%) x RBC
37
if reticulocyte index is <2% | or absolute reticulocyte count <75,000
- problem with red cell production | - HYPOPROLIFERATIVE ABNORMALITY
38
if reticulocyte index > 2% | or absolute reticulocyte count > 100,000
- good marrow response | - anemia due to blood loss (HEMORRHAGE) or red cell destruction (HEMOLYSIS)
39
microcytic anemia MCV level
- MCV <80
40
microcytic anemia tends to reflect a problem with
- problem with hemoglobin synthesis
41
macrocytic anemia MCV level
- MCV > 100
42
macrocytic anemia types
- megaloblastic | - non-megaloblastic
43
megaloblastic anemia cause
- impairment of DNA synthesis
44
normocytic anemia cause
- marrow not working well - mixed problem - acute problem
45
two approaches for treatment of anemia
- treat underlying cause | - transfusion
46
whether or not to transfuse
- how symptomatic is the patient? - can we reverse the underlying cause? - do we have enough time to treat the underlying cause?
47
hemoglobin value that should be a trigger in every patient for transfusion
- NO ABSOLUTE VALUE
48
general indications for transfusion
- cardiovascular compromise - hypo proliferative anemia with no or prolonged recovery - anemia patient going into surgery now and may lose blood
49
cardiovascular compromise conditions
- CHF - shock - angina