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Hematology > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

1
Q

meaning of Haima

A

blood

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2
Q

meaning of poiesis

A

to produce something

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3
Q

serves as a functional model to study stem BIOLOGY, PROLIFERATION, MATURATION & CONTRIBUTION to disease and tisse repair

A

hematopoietic system

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4
Q

most common theory that exist of hematopoiesis

A

unitary (monophyletic theory)

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5
Q

who introduced the monophyletic theory

A

A.A.Maksimov

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6
Q

there is a common parent cell of all forming elements of blood

A

monophyletic theory

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7
Q

includes two sources of hematopoiesis: MYELOID AND LYMPHOID

A

dualistic theory

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8
Q

also known as TRIALISTIC THEORY

A

polyphelytic theory

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9
Q

suggests different group of blood cells originate from different stem cells

A

polyphelytic theory

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10
Q

three systems of trialistic

A

myeloid, lymphoid and reticuloendothelial

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11
Q

who proposed trialistic theory

A

L. Aschoff

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12
Q

stages of hematopoietic development

A

mesoblastic, hepatic and medullary phase

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13
Q

begins during embryonic development in the blood islands in the YOLK SAC

A

mesoblastic

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14
Q

primitive hematopoiesis

A

mesoblastic

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15
Q

permanent adult hematopoiesis

A

hematopoietic stem cell

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16
Q

surrounds the cavity of the yolk sac

A

angioblast

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17
Q

embryonic hemoglobin

A

gower 1, gower 2, portland

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18
Q

primary site of hepatic phase

A

liver

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19
Q

start of definitive hematopoiesis

A

hepatic phase

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20
Q

lymphoid cells begin to appear

A

hepatic phace

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21
Q

first fully developed organ in the fetus and MAJOR SITE OF T CELL

A

thymus

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22
Q

produces B cells

A

kidney and spleen

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23
Q

HSCs and mesenchymal cells migrate into the core of the bone

A

medullary phase

24
Q

type of embryonic tissue

A

mesenchymal cells

25
Q

ratio of myeloid to erythroid

A

3:1

26
Q

primary site for medullary phase (MYELOID PHASE)

A

bone marrow

27
Q

blood cell production that occurs outside the bone marrow

A

extramedullary

28
Q

only site for production and development for post natal hematopoiesis

A

bone marrow

29
Q

one of the largest organs in the body, is the tissue located within the cavities of cortical bones

A

bone marrow

30
Q

Projections of calcified bone that radiate out from the bone cortex into the central
space

A

trabeculae

31
Q

two major components of bone marrow

A

red and yellow marrow

32
Q

how many percent does newborn has for red marrow?

A

100%

33
Q

Composed of extravascular cords that contain all
of the developing blood cell lineage, stem and
progenitor cells, adventitial cells and
macrophages

A

red marrow

34
Q

composed primarily of ADIPOCYTES (fat cells)

A

yellow marrow

35
Q

replacement of active marrow into adipose tissue

A

retrogression

36
Q

supplies blood only to the marrow

A

NUTRIENT ARTERY

37
Q

provide nutrients for the osseous bone and the marrow

A

PERIOSTEAL ARTERY

38
Q

macrophage that remove senescent cells and foreign debris from
the blood that circulates through the liver

A

KUPFFER CELLS

39
Q

happens when too many blood cells get stuck in the
spleen

A

SPLENIC SEQUESTRATION

40
Q

Contains 350 mL of blood and approximately 30% of platelets

A

Spleen

41
Q

Synthesis (transport proteins, enzymes)

A

liver

42
Q

spleen removes senescent rbc by ___________ and ______________

A

culling and pitting

43
Q

phagocytosis by macrophage

A

culling

44
Q

removal of abnormal parts only

A

pitting

45
Q

Formation of new lymphocytes from germinal centers

A

lymph nodes

46
Q

fluid portion of blood that escapes into the ct

A

lymph

47
Q

also known as the waiting zone

A

thymus

48
Q

densely populated with
progenitor lymphoid cells

A

thymus

49
Q

proposed the stem cell theory

A

Till and McCulloch

50
Q

these colonies were capable of self-renewal and the production of differentiated
progeny

A

COLONY-FORMING UNITS–SPLEEN (CFU-S)

51
Q

represents what we now refer to as committed myeloid progenitors or colony-forming
unit–granulocyte, erythrocyte, monocyte, and megakaryocyte (CFUGEMM)

A

COLONY-FORMING UNITS–SPLEEN (CFU-S)

52
Q

MONOPHYLETIC THEORY suggests that all blood cells are derived from a single progenitor stem cell called a ______________________

A

PLURIPOTENT HEMATOPOIETIC STEM CELL

53
Q

comitted cells

A

PROGENITOR CELLS

54
Q

stem cells that have developed to the stage where they are committed to forming a
particular type of new blood cell

A

precursor cells

55
Q

who proposed stochastic model

A

till and McCulloch

56
Q

the ratio between the number of cells in a
population undergoing mitosis to the total number of cells in a
population

A

mitotic index

57
Q

group of specific glycoproteins that regulate the
proliferation, differentiation, and maturation of
hematopoietic precursor cells

A

cytokines

Hematology (5 decks)

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