Hematopoiesis Flashcards
meaning of Haima
blood
meaning of poiesis
to produce something
serves as a functional model to study stem BIOLOGY, PROLIFERATION, MATURATION & CONTRIBUTION to disease and tisse repair
hematopoietic system
most common theory that exist of hematopoiesis
unitary (monophyletic theory)
who introduced the monophyletic theory
A.A.Maksimov
there is a common parent cell of all forming elements of blood
monophyletic theory
includes two sources of hematopoiesis: MYELOID AND LYMPHOID
dualistic theory
also known as TRIALISTIC THEORY
polyphelytic theory
suggests different group of blood cells originate from different stem cells
polyphelytic theory
three systems of trialistic
myeloid, lymphoid and reticuloendothelial
who proposed trialistic theory
L. Aschoff
stages of hematopoietic development
mesoblastic, hepatic and medullary phase
begins during embryonic development in the blood islands in the YOLK SAC
mesoblastic
primitive hematopoiesis
mesoblastic
permanent adult hematopoiesis
hematopoietic stem cell
surrounds the cavity of the yolk sac
angioblast
embryonic hemoglobin
gower 1, gower 2, portland
primary site of hepatic phase
liver
start of definitive hematopoiesis
hepatic phase
lymphoid cells begin to appear
hepatic phace
first fully developed organ in the fetus and MAJOR SITE OF T CELL
thymus
produces B cells
kidney and spleen
HSCs and mesenchymal cells migrate into the core of the bone
medullary phase
type of embryonic tissue
mesenchymal cells
ratio of myeloid to erythroid
3:1
primary site for medullary phase (MYELOID PHASE)
bone marrow
blood cell production that occurs outside the bone marrow
extramedullary
only site for production and development for post natal hematopoiesis
bone marrow
one of the largest organs in the body, is the tissue located within the cavities of cortical bones
bone marrow
Projections of calcified bone that radiate out from the bone cortex into the central
space
trabeculae
two major components of bone marrow
red and yellow marrow
how many percent does newborn has for red marrow?
100%
Composed of extravascular cords that contain all
of the developing blood cell lineage, stem and
progenitor cells, adventitial cells and
macrophages
red marrow
composed primarily of ADIPOCYTES (fat cells)
yellow marrow
replacement of active marrow into adipose tissue
retrogression
supplies blood only to the marrow
NUTRIENT ARTERY
provide nutrients for the osseous bone and the marrow
PERIOSTEAL ARTERY
macrophage that remove senescent cells and foreign debris from
the blood that circulates through the liver
KUPFFER CELLS
happens when too many blood cells get stuck in the
spleen
SPLENIC SEQUESTRATION
Contains 350 mL of blood and approximately 30% of platelets
Spleen
Synthesis (transport proteins, enzymes)
liver
spleen removes senescent rbc by ___________ and ______________
culling and pitting
phagocytosis by macrophage
culling
removal of abnormal parts only
pitting
Formation of new lymphocytes from germinal centers
lymph nodes
fluid portion of blood that escapes into the ct
lymph
also known as the waiting zone
thymus
densely populated with
progenitor lymphoid cells
thymus
proposed the stem cell theory
Till and McCulloch
these colonies were capable of self-renewal and the production of differentiated
progeny
COLONY-FORMING UNITS–SPLEEN (CFU-S)
represents what we now refer to as committed myeloid progenitors or colony-forming
unit–granulocyte, erythrocyte, monocyte, and megakaryocyte (CFUGEMM)
COLONY-FORMING UNITS–SPLEEN (CFU-S)
MONOPHYLETIC THEORY suggests that all blood cells are derived from a single progenitor stem cell called a ______________________
PLURIPOTENT HEMATOPOIETIC STEM CELL
comitted cells
PROGENITOR CELLS
stem cells that have developed to the stage where they are committed to forming a
particular type of new blood cell
precursor cells
who proposed stochastic model
till and McCulloch
the ratio between the number of cells in a
population undergoing mitosis to the total number of cells in a
population
mitotic index
group of specific glycoproteins that regulate the
proliferation, differentiation, and maturation of
hematopoietic precursor cells
cytokines