Hematopoiesis

Question 1

meaning of Haima

Answer 1

blood

Question 2

meaning of poiesis

Answer 2

to produce something

Question 3

serves as a functional model to study stem BIOLOGY, PROLIFERATION, MATURATION & CONTRIBUTION to disease and tisse repair

Answer 3

hematopoietic system

Question 4

most common theory that exist of hematopoiesis

Answer 4

unitary (monophyletic theory)

Question 5

who introduced the monophyletic theory

Answer 5

A.A.Maksimov

Question 6

there is a common parent cell of all forming elements of blood

Answer 6

monophyletic theory

Question 7

includes two sources of hematopoiesis: MYELOID AND LYMPHOID

Answer 7

dualistic theory

Question 8

also known as TRIALISTIC THEORY

Answer 8

polyphelytic theory

Question 9

suggests different group of blood cells originate from different stem cells

Answer 9

polyphelytic theory

Question 10

three systems of trialistic

Answer 10

myeloid, lymphoid and reticuloendothelial

Question 11

who proposed trialistic theory

Answer 11

L. Aschoff

Question 12

stages of hematopoietic development

Answer 12

mesoblastic, hepatic and medullary phase

Question 13

begins during embryonic development in the blood islands in the YOLK SAC

Answer 13

mesoblastic

Question 14

primitive hematopoiesis

Answer 14

mesoblastic

Question 15

permanent adult hematopoiesis

Answer 15

hematopoietic stem cell

Question 16

surrounds the cavity of the yolk sac

Answer 16

angioblast

Question 17

embryonic hemoglobin

Answer 17

gower 1, gower 2, portland

Question 18

primary site of hepatic phase

Answer 18

liver

Question 19

start of definitive hematopoiesis

Answer 19

hepatic phase

Question 20

lymphoid cells begin to appear

Answer 20

hepatic phace

Question 21

first fully developed organ in the fetus and MAJOR SITE OF T CELL

Answer 21

thymus

Question 22

produces B cells

Answer 22

kidney and spleen

Question 23

HSCs and mesenchymal cells migrate into the core of the bone

Answer 23

medullary phase

Question 24

type of embryonic tissue

Answer 24

mesenchymal cells

Question 25

ratio of myeloid to erythroid

Answer 25

3:1

Question 26

primary site for medullary phase (MYELOID PHASE)

Answer 26

bone marrow

Question 27

blood cell production that occurs outside the bone marrow

Answer 27

extramedullary

Question 28

only site for production and development for post natal hematopoiesis

Answer 28

bone marrow

Question 29

one of the largest organs in the body, is the tissue located within the cavities of cortical bones

Answer 29

bone marrow

Question 30

Projections of calcified bone that radiate out from the bone cortex into the central space

Answer 30

trabeculae

Question 31

two major components of bone marrow

Answer 31

red and yellow marrow

Question 32

how many percent does newborn has for red marrow?

Answer 32

100%

Question 33

Composed of extravascular cords that contain all of the developing blood cell lineage, stem and progenitor cells, adventitial cells and macrophages

Answer 33

red marrow

Question 34

composed primarily of ADIPOCYTES (fat cells)

Answer 34

yellow marrow

Question 35

replacement of active marrow into adipose tissue

Answer 35

retrogression

Question 36

supplies blood only to the marrow

Answer 36

NUTRIENT ARTERY

Question 37

provide nutrients for the osseous bone and the marrow

Answer 37

PERIOSTEAL ARTERY

Question 38

macrophage that remove senescent cells and foreign debris from the blood that circulates through the liver

Answer 38

KUPFFER CELLS

Question 39

happens when too many blood cells get stuck in the spleen

Answer 39

SPLENIC SEQUESTRATION

Question 40

Contains 350 mL of blood and approximately 30% of platelets

Answer 40

Spleen

Question 41

Synthesis (transport proteins, enzymes)

Answer 41

liver

Question 42

spleen removes senescent rbc by ___________ and ______________

Answer 42

culling and pitting

Question 43

phagocytosis by macrophage

Answer 43

culling

Question 44

removal of abnormal parts only

Answer 44

pitting

Question 45

Formation of new lymphocytes from germinal centers

Answer 45

lymph nodes

Question 46

fluid portion of blood that escapes into the ct

Answer 46

lymph

Question 47

also known as the waiting zone

Answer 47

thymus

Question 48

densely populated with progenitor lymphoid cells

Answer 48

thymus

Question 49

proposed the stem cell theory

Answer 49

Till and McCulloch

Question 50

these colonies were capable of self-renewal and the production of differentiated progeny

Answer 50

COLONY-FORMING UNITS–SPLEEN (CFU-S)

Question 51

represents what we now refer to as committed myeloid progenitors or colony-forming unit–granulocyte, erythrocyte, monocyte, and megakaryocyte (CFUGEMM)

Answer 51

COLONY-FORMING UNITS–SPLEEN (CFU-S)

Question 52

MONOPHYLETIC THEORY suggests that all blood cells are derived from a single progenitor stem cell called a ______________________

Answer 52

PLURIPOTENT HEMATOPOIETIC STEM CELL

Question 53

comitted cells

Answer 53

PROGENITOR CELLS

Question 54

stem cells that have developed to the stage where they are committed to forming a particular type of new blood cell

Answer 54

precursor cells

Question 55

who proposed stochastic model

Answer 55

till and McCulloch

Question 56

the ratio between the number of cells in a population undergoing mitosis to the total number of cells in a population

Answer 56

mitotic index

Question 57

group of specific glycoproteins that regulate the proliferation, differentiation, and maturation of hematopoietic precursor cells

Answer 57

cytokines