Erythropoiesis

Question 1

the process of rbc production

Answer 1

erythropoiesis

Question 2

rbc production normally occurs in?

Answer 2

bone marrow

Question 3

adult hematopoiesis production sites

Answer 3

verterbrae, ribs, sternum, skull and proximal ends of the femur and humerus

Question 4

formal name of rbc

Answer 4

erythrocytes

Question 5

nucleated precursors in the bone marrow

Answer 5

erythroblast

Question 6

refers to developing nucleated cells with normal appearance

Answer 6

normoblast

Question 7

abnormal appearance (large size) of the developing nucleated cells in megaloblastic anemia

Answer 7

megaloblast

Question 8

days required to produce a mature rbc from the BFU-E

Answer 8

18-21 days

Question 9

the color of rbc changes when it matures, it turns from blue to _______ and then ______.

Answer 9

gray and pink

Question 10

it is when globin production begins

Answer 10

pronormoblast

Question 11

detectable hemoglobin occurs

Answer 11

basophilic normoblast

Question 12

last stage in which the cell is capable of undergoing mitosis

Answer 12

polychromatic normoblast

Question 13

salmon-pink color of the cytoplasm reflects nearly complete HEMOGLOBIN production

Answer 13

orthocromic normoblast

Question 14

in polychromatic erythrocyte, it can be stained using __________ or ____________.

Answer 14

methylene blue or brillian cresyl blue

Question 15

matured erythrocyte remains active in the circulation for how many days?

Answer 15

120 days

Question 16

describes the dynamics of rbc production and destruction

Answer 16

erythrokinetics

Question 17

collection of all stages of erythrocytes in the body

Answer 17

erythron

Question 18

cells in circulation

Answer 18

rbc mass

Question 19

promote early release of reticulocytes

Answer 19

erythropoietin

Question 20

deliver and transport of oxygen DOES NOT REQUIRE ENERGY

Answer 20

erythrocyte metabolism

Question 21

responsible for 90% of ATP

Answer 21

anaerobic glycolitic pathway (embden meyerhof pathway)

Question 22

responsible for 10% ATP, also known as hexose monophosphate pathway

Answer 22

pentose phospate pathway

Question 23

able to convert oxidized heme iron to its reduced state

Answer 23

methemoglobin reductase pathway

Question 24

necessary for the facilitation of oxygen delivery to the tissues

Answer 24

rapaport-luebering pathway

Question 25

prevents loss of rbc membrane

Answer 25

deformability

Question 26

prevent colloid hemolysis

Answer 26

permeability

Question 27

cell aging

Answer 27

senescence

Question 28

extravascular hemolysis occurs in which organ?

Answer 28

spleen

Question 29

erythrocyte death as a nonnucleated cell version of apoptosis

Answer 29

eryptosis

Question 30

when the iron is removed from the heme, it can be stored in the macrophage as __________until transported out

Answer 30

ferritin

Question 31

carry oxygen and c02

Answer 31

hemoglobin

Question 32

carries Fe to developing RBCs

Answer 32

transferrin

Question 33

produced on specific ribosomes in the cytoplasm of RBCs

Answer 33

globin

Question 34

molecular strucure of gower 1

Answer 34

2 zeta, 2 epsilon

Question 35

molecular strucure of gower 2

Answer 35

2 alpha, 2 epilson

Question 36

molecular strucure of portland

Answer 36

2 zeta, 2 gamma

Question 37

molecular strucure of fetal (HbF)

Answer 37

2 alpha, 2 gamma

Question 38

molecular strucure of HbA-1

Answer 38

2 alpha, 2 beta

Question 39

molecular strucure of HbA-2

Answer 39

2 alpha, 2 delta

Question 40

stage of life of gower 1, gower 2 and portland

Answer 40

embryonic

Question 41

stage of life of fetal (HbF), HbA-1 and HbA-2

Answer 41

newborn & adult

Question 42

range of HbA-1 in adults

Answer 42

92%-95%

Question 43

range of HbA-2 in adults

Answer 43

2%-3%

Question 44

range of HbF in adults

Answer 44

1%-2%

Question 45

1g Hb is equals to

Answer 45

1.34 mL of oxygen

Question 46

the affinity of Hb for oxygen depends on _______________

Answer 46

partial pressure of oxygen

Question 47

the amount of oxygen needed to saturate 50% of hemoglobin is called

Answer 47

P50 value

Question 48

P50 value ranges normally around ________

Answer 48

27 mmHg

Question 49

factors causing the odc to shift to the right

Answer 49

increase co2, acidity, dpg, temperature

Question 50

shifts to curve to the left or right occur if there are changes in the pH of blood

Answer 50

bohr effect

Question 51

alkalosis, methemoglobenomia, increased carboxyhemoglobin

Answer 51

shift to the left

Question 52

high fever, acidosis, conditions that produces hypoxia

Answer 52

shift to the right